Immunological Competence and Nutritional Status in Patients with Lung Cancer

Shirai, Ryo; Kadota, Jun‐ichi; Iida, Kei; Kawakami, K.; Abe, Koh; Yoshinaga, M; Iwashita, Tetsuji; Matsubara, Y; Oka, M.; Kohno, Shigeru

doi:10.1007/pl00007618

Cited by 13 publications

(17 citation statements)

References 22 publications

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“…The fact that AGP was increased in the serum of septic patients and that the cytokines are major modulators of AGP gene expression (20) indicates the importance of determining whether the inhibitory effect of cytokines on neutrophil migration is also an AGP-dependent process. Moreover, it is also important to determine whether AGP is the serum factor that mediates the reduction of neutrophil migration reported for other diseases, such as diabetes (10), cirrhosis (11), AIDS (12), and cancer (13).…”

Section: Discussionmentioning

confidence: 99%

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Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Mestriner¹,

Spiller²,

Laure

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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The reduction of circulating neutrophil migration to infection sites is associated with a poor outcome of severe sepsis. ␣-1-Acid glycoprotein (AGP) was isolated from the sera of severely septic patients by HPLC and acrylamide gel electrophoresis and identified by mass spectrometry. Both the isolated protein and commercial AGP inhibited carrageenin-induced neutrophil migration into the rat peritoneal cavity when administered i.v. at a dose of 4.0 g per rat (95 pmol per rat). Analysis by intravital microscopy demonstrated that both proteins inhibited the rolling and adhesion of leukocytes in the mesenteric microcirculation. The inhibitory activity was blocked by 50 mg/kg aminoguanidine, s.c., and was not demonstrable in inducible nitric oxide synthase (iNOS) knockout mice. Incubation of AGP with neutrophils from healthy subjects induced the production of NO and inhibited the neutrophil chemotaxis by an iNOS/NO/cyclic guanosine 3,5-monophosphatedependent pathway. In addition, AGP induced the L-selectin shedding by neutrophils. The administration of AGP to rats with mild cecal ligation puncture sepsis inhibited neutrophil migration and reduced 7-day survival from Ϸ80% to 20%. These data demonstrate that AGP, an acute-phase protein, inhibits neutrophil migration by an NO-dependent process and suggest that AGP also participates in human sepsis.

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Section: Discussionmentioning

confidence: 99%

“…Serum factors have also been reported to play a role in the reduced neutrophil migration in other diseases, such as diabetes (10), cirrhosis (11), AIDS (12), and cancer (13). All of these diseases are associated with high susceptibility to infection.…”

mentioning

confidence: 99%

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Mestriner¹,

Spiller²,

Laure

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…Changes of ROS production by PMN were observed in different types of cancer (16)(17). In our experiments, PMA was used for induction of ROS in isolated PMN.…”

Section: Nm and 25 Nm) Ros Production Was Determined By Flow Cytomementioning

confidence: 97%

Peripheral Blood Neutrophil Granulocytes from Patients with Head and Neck Squamous Cell Carcinoma Functionally Differ from Their Counterparts in Healthy Donors

Trellakis

Farjah

Bruderek

et al. 2011

Int J Immunopathol Pharmacol

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Solid tumors such as head and neck squamous cell carcinoma (UNSee) display an intense interaction between tumoral factors and the immune system. Functional modulation of tumor-infiltrating and peripheral blood immune cells plays an important role during tumor progression. In this pilot study we compared biological functions of polymorphonuclear granulocytes (PMN) from the peripheral blood of UNSee patients and healthy subjects. PMN were simultaneously isolated from the peripheral blood of UNSee patients and healthy donors for functional analysis (apoptosis, production of reactive oxygen species (ROS), cytokine release and immunophenotyping). PMN from UNSee patients showed a significantly lower inducible production of ROS (P = 0.02) and reduced spontaneous apoptosis (P = 0.008) compared with PMN from healthy donors. Under standard culture conditions, there was no significant difference regarding the release of inflammatory cytokines between PMN from UNSee patients and PMN from healthy donors. Confirming previous observations, serum concentrations of PMN-related cytokines were significantly higher in the peripheral blood of UNSee patients than in that of controls. Importantly, immunophenotyping revealed an increased number of immature PMN in PMN fractions isolated from UNSee patients. Peripheral blood PMN from UNSee patients and healthy donors show distinct functional differences. The presence of increased numbers of immature stages of PMN in UNSee patients may partly contribute to the changes observed. After recruitment to and infiltration of the tumor, PMN may be further modulated in the local tumor microenvironment. This pilot study justifies functional analyses of myeloid cells in larger cohorts of patients with UNSee.Cancer-related inflammation in solid tumors is associated with modulation of immune cells finally resulting in tumor progression (I). Head and neck squamous cell carcinoma (HNSCC) displays frequent infiltration by various immune effector cells and reciprocal interaction between tumor and immune cells. This interaction leads to an increased local and systemic expression of immune-modulating mediators, often resulting in immuno-suppression and the escape of the tumor from immune control (2). Accumulating evidence suggests that polymorphonuclear granulocytes (PMN, neutrophils) and other myeloid cells play an important tumor-promoting role during tumor progression (3-4). In the tumor host, tumor-derived factors modulate PMN functions: For instance, in bronchioalveolar carcinoma, production of antiapoptotic factors by the tumor

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“…TPN support is considered beneficial to improve the patients' nutritional status and immune function, and to lower the surgical complications, and to improve the quality of life [22][23][24][25][26][27][28] . But, TPN can also stimulate proliferation of the tumor cells [29,30] .…”

Section: Discussionmentioning

confidence: 99%

Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism

Xiao¹,

Cao²,

Yin³

et al. 2001

WJG

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AIM To investigate the influence of L-methioninedeprived total parenteral nutrition with 5-FU on gastric cancer and host metabolism.METHODS N-methyl-N'-nitro-nitrosoguanidine (MNNG) induced gastric cancer rats were randomly divided into four groups: Met-containing TPN group (n = 11), Metdeprived TPN group (n = 12), Met-containing TPN+5-FU group (n = 11) and Met-deprived TPN+5-FU group (n = 12). Five rats in each group were sacrificed after 7 days of treatment and the samples were taken for examination. The remaining rats in each group were then fed separately with normal diet after the treatment until death, the life span was noted.RESULTS The tumors were enlarged in Met-containing group and shrank in Met-deprived group markedly after the treatment. The DNA index (DI) of tumor cells and the body weight (BW) of rats had no significant change in the two groups, however, the ratio of tumor cells' S phase was increased. The ratio of G2M phase went up in Met-containing group, but down in Metdeprived group. In the other two groups that 5-FU was added, the BW of rats, and the diameter of tumors, the DI of tumor cells, the S and G2M phase ratio of tumor cells were all decreased, particularly in Metdeprived plus 5-FU group. Pathological examination revealed that the necrotic foci of the tumor tissue increased after Met-deprived TPN treatment, and the nucleoli of tumor cells enlarged. In -MetTPN+5-FU group, severe nuclear damage was also found by karyopyknosis and karyorrhexis, meanwhile there was slight degeneration in some liver and kidney cells. The serum free Met and Cysteine decreased markedly (P<0.001), while other amino acids, such as serum free serine and glutamine increased significantly (P<0.005). All the rats died of multiple organ failure caused by cancer metastasis. The average survival time was 18.6 days in Met-containing TPN group, 31 days in Metdeprived TPN group, 27.5 days in Met-containing TPN+5-FU group, and 43 days in Met-deprived TPN+5-FU group (P<0.05).

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Immunological Competence and Nutritional Status in Patients with Lung Cancer

Cited by 13 publications

References 22 publications

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Peripheral Blood Neutrophil Granulocytes from Patients with Head and Neck Squamous Cell Carcinoma Functionally Differ from Their Counterparts in Healthy Donors

Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism

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