“…Although most of these MAbs have been ineffective in neutralizing the polymerase activities of RT (Hansen et al, 1988;Tisdale et al, 1988;Ferris et aI., 1990;Li et at., 1993), a few inhibitory MAbs have been reported (Ferns et al, 1991;Orvell et al, 1991;Szilvay et al, 1992;Restle et al, 1992;Wu et al, 1993), and these may point to functionally important sites of RT. For example, MAb 28 (Restle et at., 1992) and MAb 1E8 (Wu et al, 1993) are involved in blocking binding of deoxynucleoside triphosphate substrate to the enzyme.…”