2016
DOI: 10.4269/ajtmh.15-0386
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Immunological Characteristics of Recurrent Echinococcosis-Induced Anaphylactic Shock

Abstract: Abstract. Anaphylactic shock represents a serious complication of echinococcosis as up to 4.6% of patients die as a result of its severity and improper handling. Once a definite diagnosis is made, effective treatments need to be immediately initiated. Here, we report the immunological characteristics and management of two patients with recurrent anaphylactic shock concurrent with the surgical removal of hydatid cysts. Both patients had systemic echinococcosis classified as cystic echinococcosis type 2 (CE2) wi… Show more

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Cited by 6 publications
(6 citation statements)
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References 20 publications
(22 reference statements)
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“…When endothelial cells detach from the underlying extracellular matrix, apoptosis occurs, resulting in endothelial cell damage due to TLR4 activation and inflammatory factors such as TNF‐α 35 . A significant increase in inflammatory factors such as TNF‐α has also been observed in previous studies, 6 which induce cellular apoptosis 36 and pyroptosis 37 while promoting an inflammatory response in cells and tissues. FAK tyrosine phosphorylation can inhibit cellular apoptosis through the PI3K signaling pathway 35 .…”
Section: Discussionmentioning
confidence: 78%
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“…When endothelial cells detach from the underlying extracellular matrix, apoptosis occurs, resulting in endothelial cell damage due to TLR4 activation and inflammatory factors such as TNF‐α 35 . A significant increase in inflammatory factors such as TNF‐α has also been observed in previous studies, 6 which induce cellular apoptosis 36 and pyroptosis 37 while promoting an inflammatory response in cells and tissues. FAK tyrosine phosphorylation can inhibit cellular apoptosis through the PI3K signaling pathway 35 .…”
Section: Discussionmentioning
confidence: 78%
“…However, an increase in neutrophils would result in pyroptosis by secreting IL‐1β 34 . Previous research has also documented the activation and increase in neutrophils 6 . In the focal adhesion signaling pathway, focal adhesion kinase (FAK) is an essential part of the basal cell adhesion, which is called the focal adhesion complex.…”
Section: Discussionmentioning
confidence: 99%
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“…Den Schaden richten die Parasiten erst im Verlauf an, wobei Leber und Lunge zu 90 % die primären Zielorgane sind [5]. Im Abdomen führen Rupturen der Zysten primär zur Anaphylaxie, die in 4,6 % letal verläuft, und zum akuten Abdomen mit Ileus [2,5,6]. Rupturen können selten spontan (1-8 %), häufiger traumatisch entstehen, wobei schon eine vermehrte körperliche Belastung [2,7] ausreichen kann.…”
Section: Diskussionunclassified
“…If misdiagnosed, secondary infections and severe allergic reactions can occur. When the lesion is punctured and drained, it will also cause hydatid fluid and hydatid sand protoscoleces to leak and spread, which will affect the human body, causing greater harm (Ye et al 2016 ; Mohammed et al 2021 ). Therefore, it is very important to improve the differential diagnosis of pulmonary CE and pulmonary abscess.…”
Section: Introductionmentioning
confidence: 99%