Immunological changes and stress are associated with different implantation rates in patients undergoing in vitro fertilization–embryo transfer

Gallinelli, Andrea; Roncaglia, R; Matteo, Maria Lucia; Ciaccio, I; Volpe, Annibale; Facchinetti, Fabio

doi:10.1016/s0015-0282(01)01826-x

Cited by 75 publications

(40 citation statements)

References 32 publications

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“…A prolonged period of stress and anxiety has also been associated with high amounts of activated T cells in the peripheral blood. In turn, such immunological changes are associated with reduced implantation rates in women undergoing IVF [19]. Although it was proposed that encouraging patients to follow their daily routine immediately after ET might help them to cope with anxiety, this might not be true for all cases.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Instant Urinary Catheterization on Pregnancy Outcomes after Intracytoplasmic Sperm Injection and Embryo Transfer

Olgan

Dırıcan²

2017

Gynecol Obstet Invest

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Aim: To evaluate the effect of instant urinary catheterization on pregnancy rates in women who are on bed rest after embryo transfer (ET). Methods: This retrospective study included patients who underwent intracytoplasmic sperm injection (ICSI) treatment at the Akdeniz University Fertility Clinic between January 2015 and March 2016. All patients were advised bed rest for an hour after ET. The clinic's electronic database was screened to identify the uterine anatomy of the patients, transferred embryo quality, and urinary catheterization status. Only women with an anteverted and anteflexed uterus and cycles that resulted in high-quality blastocyst transfers were included in this analysis. Finally, 71 cycles with urinary catheterization and 81 cycles with no catheterization were analyzed. Results: The clinical (53.5 vs. 40.7%, p = 0.115) and ongoing pregnancy (43.7 vs. 35.8%, p = 0.323) rates were comparable between urinary catheterization and non-catheterization groups. Multivariate analysis by logistic regression including confounding factors revealed that urinary catheterization was independently associated with clinical pregnancy (OR 2.06, 95% CI 1.03-4.13, p = 0.041). However, no significant association was detected between catheterization and the clinically more relevant, ongoing pregnancy (OR 1.65, 95% CI 0.82-3.30, p = 0.160). Conclusion: Our preliminary findings on the use of instant urinary catheterization after ET are promising and justify further investigation in larger prospective studies.

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Section: Discussionmentioning

confidence: 99%

The Effect of Instant Urinary Catheterization on Pregnancy Outcomes after Intracytoplasmic Sperm Injection and Embryo Transfer

Olgan

Dırıcan²

2017

Gynecol Obstet Invest

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“…Personality tests are the most common method to identify traits that correlate to aberrant stress response with poor reproductive outcome (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). However, despite the wide array of testing, no consistent personality characteristic has been identified.…”

Section: How Is An Aberrant Stress Response Currently Measured?mentioning

confidence: 99%

“…Physiologic responses are thought to be less subjective than personality tests and have also been studied as stress response markers, with similar mixed results (6,11,16). Finally, various biochemical markers of acute (1,11,15,17) and chronic (1,22,23) stress have been studied. Unfortunately, the correlation between these markers and poor reproductive outcome have been subtle or nonexistent.…”

Section: How Is An Aberrant Stress Response Currently Measured?mentioning

confidence: 99%

“…The studies on the association between an aberrant stress response and poor fertility outcomes are mixed, with studies supporting an association (1,6,8,11,12,15,17,22,(24)(25)(26), studies refuting an association (13,18,(27)(28)(29), and even a study suggesting a positive impact of stress on reproduction (14). In addition, there are studies demonstrating a negative impact of stress on male reproduction (19,30,31).…”

Section: Does Stress Negatively Impact Fertility?mentioning

confidence: 99%

“…There is also ample anecdotal and documented evidence demonstrating that the diagnosis of infertility and the process of IVF are stressful events (10,11,20,21,32,33). Few life experiences rival infertility assessment in its level of personal invasiveness, which certainly increases stress.…”

Section: Does Stress Negatively Impact Fertility?mentioning

confidence: 99%

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