Immunological Aspects of Wart Regression With Special Reference to Regression Phenomenon of Numerous Flat Warts

Tagami, Hachiro; Oguchi, Motoi; Ofuji, Shigeo

doi:10.1111/j.1346-8138.1983.tb01098.x

Cited by 21 publications

(7 citation statements)

References 43 publications

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“…A similar inflammatory reaction has been described in regressing plane warts, in which high densities of mononuclear cells were found and T8+ lymphocytes outnumbered T4-1lymphocytes (Tagami et al, 1983;Tagami, Oku & Iwatsuki, 1985). In two cases of cutaneous warts, an increase of T cells has been reported in which there was a predominance of helper/ inducer T cells (Gatter et al, 1984b).…”

Section: Discussionsupporting

confidence: 66%

Langerhans cells in human warts

1986

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Seventy-six warts (15 plantar, 38 hand, 16 miscellaneous and seven anogenital lesions) taken from 55 patients, were studied by indirect immunofluorescence with monoclonal antibodies specific for T-cell subsets, Langerhans cells (LC) and HLA-DR antigen. The results were related to the presence of viral antigen. Approximately 80% of the lesions showed an infiltrate. Only 19 lesions contained helper/inducer or suppressor/cytotoxic T cells. The distribution of LC was abnormal in 65% of biopsies which contained LC in the dermis, and 29% were devoid of LC in the epidermis. Many lesions had reduced numbers of LC in the epidermis. The disappearance of LC from the epidermis was related to the presence of viral antigen, but not to the presence of particular T-cell subsets. Infiltrating cells were sometimes HLA-DR-positive, whereas basal cells did not express HLA-DR antigen, irrespective of the density of the infiltrate.

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Section: Discussionsupporting

confidence: 66%

Langerhans cells in human warts

1986

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“…Inflammation is a typical finding in conjunctival papillomas and may indicate a cell mediated immune response to HPV infection (Tagami 1983).…”

Section: Discussionmentioning

confidence: 99%

Conjunctival papilloma

Sjö

Heegaard

Prause

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine morphological and clinical characteristics of conjunctival papilloma. Methods: Specimens of conjunctival papilloma registered during the period 1983-1997 were collected. For each case the patient's sex and age, number of papillomas/patient, seasonal debut, duration, number of recurrences, localisation and presence of dysplasia and/or inflammation in the papilloma were registered. Results: A total of 245 papillomas in 219 patients were found. 132 (60.3%) of the patients were males. The age distribution showed skewness to the left with a peak in the age groups 20-29 years and 30-39 years. No variation of seasonal debut was found. 14 patients (6%) had more than one papilloma concurrently. 24 (11%) of the patients had recurrence. Most of the papillomas were located medially and inferiorly. 98 (40%) of the papillomas were inflamed. 14 (6%) of the papillomas were dysplastic. Conclusion:The conjunctival papilloma is a common tumour. More males than females develop conjunctival papillomas and the incidence is highest among patients aged 20-39 years. The conjunctival papilloma is primarily located medially and inferiorly.Key words: papilloma -conjunctiva -localisation -dysplasia -sex -age -distribution. T he squamous cell papilloma of the conjunctiva is a benign and common epithelial tumour.Conjunctival papillomas may have an exophytic, mixed or inverted growth pattern (Conlon et al. 1994;Streeten et al. 1979). The exophytic configuration may be sessile or pedunculated. Inverted papillomas of the conjunctiva are very rare (Streeten et al. 1979).Dysplasia may be observed, but carcinoma rarely develops in a conjunctival papilloma (Zimmerman 1980).In a study of 1016 epibulbar lesions (Ash 1950) the conjunctival papilloma was found to be the second most frequent epithelial lesion and the conjunctival papilloma is an equally frequent lesion of the caruncle (Santos & Gó mez-Leal 1994).The aetiology of the conjunctival papilloma is not known, but it has been associated with human papillomavirus (HPV) types 6,11 and 16 (McDonnell et al. 1987;Saegusa et al. 1995). HPV types 16 and 18 have in addition been found in normal conjunctival tissue (Karcioglu 1997). Material and MethodsThe files at the Eye Pathology Institute, University of Copenhagen, Denmark were reviewed for the period 1983 to 1997, included. Specimens diagnosed as a conjunctival papilloma were identified.The following data were registered from the pathology referral forms: the patient's sex and age, number of papillomas/patient, seasonal debut of the papilloma, duration, number of recurrences, the affected eye (right or left), localisation and presence of dysplasia and/or inflammation in the papilloma.A chi-squared test was used in order to test for associations between the following parameters: sex and localisation of the papilloma, localisation and affected eye and sex and age-distribution. A probability level of pϽ0.05 was considered significant. ResultsA total number of 245 papillomas in 219 patients were registered. The chi-squared...

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“…Furthermore, the patients with epidermodysplasia verruciformis, a rare hereditary disease with papilloma virus etiology, have reduced numbers of T cells and defective T cell responsiveness [6]. Direct histological evidence on the immune rejection of flat warts has also been presented [21]. Because papilloma viruses do not grow in cell cultures, viral antigens have been difficult to prepare, and the immune response in papilloma virus infections is poorly characterized.…”

Section: Introductionmentioning

confidence: 98%

Generation of cell-mediated cytotoxicity against bovine-papilloma-virus-transformed primary mouse cell lines

Laatikainen

Karjalainen

Sarkkinen

et al. 1990

Cancer Immunol Immunother

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The immunogenicity and immunosensitivity of primary mouse cell lines transformed by bovine papilloma virus 1 (BPV1) DNA were studied in a syngeneic mouse model by determining cell-mediated cytotoxicity in the spleens of mice immunized with the transformed cells. One of the cell lines induced the generation of cell-line-specific Thy1.2-positive cytotoxic effector cells. However, most of the cell lines tested induced the generation of Thy1.2-positive effector cells, which in addition to BPV1-transformed cells were able to lyse a syngeneic cell line transformed by methylcholanthrene. The lysis of BPV1- and methylcholanthrene-transformed cell lines was mediated by recognition of the same antigenic determinants expressed on these cells, and all the BPV1-transformed cell lines were sensitive to lysis by these nonspecific effector cells of the lymphokine-activated killer (LAK) type.

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Immunological Aspects of Wart Regression With Special Reference to Regression Phenomenon of Numerous Flat Warts

Cited by 21 publications

References 43 publications

Langerhans cells in human warts

Langerhans cells in human warts

Conjunctival papilloma

Generation of cell-mediated cytotoxicity against bovine-papilloma-virus-transformed primary mouse cell lines

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