Immunological Aspects of Gastro-Intestinal Pathology

Skinner, John M.; Whitehead, Robert H.

doi:10.1007/978-3-642-66481-6_8

Cited by 7 publications

(3 citation statements)

References 104 publications

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“…Comparisons based solely on cell density may provide false information to this end, a fact also pointed out by Skinner and Whitehead. 26 'Tissue unit' recording was difficult to apply on the appendix mucosa, however, because of its content of numerous lymphoid follicles. We therefore developed a method to determine the immunocyte density of the lamina propria in a representative manner, including all layers of the mucosa.…”

Section: Overall Lamina Propriamentioning

confidence: 99%

Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

Bjerke¹,

Brandtzæg²,

Rognum³

1986

Gut

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SUMMARY The densities of IgG-, IgA-, IgM-and IgD-producing immunocytes were determined by paired immunofluorescence staining and morphometric analysis in the lamina propria of normal appendix specimens. Normal colon specimens were used as reference material, mostly paired from individual subjects. The density (median of cells/mm2 lamina propria area) of IgA immunocytes tended to be slightly higher in the appendix than in the colon (1259 vs 962) and the same held true for IgM cells (71 vs 55). Conversely, the overall density of IgG immunocytes was much higher in the appendix than in the colon (95 vs 38). A striking feature was the fact that almost 50% of all immunocytes were of the IgG isotype adjacent to lymphoid follicles. It seemed justified to conclude, therefore, that the abundance of such follicles explains the overall enrichment of IgG-producing cells in normal appendix mucosa. These immunocytes most likely represent follicle derived B cells that have reached terminal maturation locally, whereas precursors generated from less mature memory clones probably emigrate and home ubiquitously to distant sites of the gut lamina propria where they develop into IgA-producing immunocytes.

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Section: Overall Lamina Propriamentioning

confidence: 99%

Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

Bjerke¹,

Brandtzæg²,

Rognum³

1986

Gut

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“…The points falling in the various layers of the mucosa were counted and their volume densities calculated. A fuller account of this technique is given by Skinner and Whitehead (1976). The theoretical accuracy of the point counting can be estimated using the equation given by Weibel (1963).…”

Section: Point Countingmentioning

confidence: 99%

Changes in enzyme activity in normal and histologically inflamed oesophageal epithelium.

Hopwood¹,

Ross²,

Logan³

et al. 1979

Gut

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“…36], We have recently provided quantitative evidence that patients with fundic atrophic gastritis, with or without PA. have hyperpla sia of fundic mucosal argyrophil endocrine cells [3]. Planimetry [3,39,40] of Grimeliusstained tissue sections from multiple stan dardized fundic mucosal biopsy specimens in unselccted patients with PA (n = 40), patients with achlorhydric fundic atrophic gastritis without PA (n = 15) and normal controls (n = 8) [3] showed significant differences in the relative amounts of argyrophil cells between patients and controls, and between patients with PA and patients with simple atrophic gastritis, the values being highest in PA (p 0.02 and p = 0.002, respectively; MannWhitney test). In patients as well as in normal controls, the main part of the argyrophil cells were situated in the basal half of the fundic mucosa and, most frequently, in association with glandular tissue.…”

Section: Gastric Endocrine Cell Hyperplasia and Circulating Gastrinmentioning

confidence: 99%

Endocrine Cell Proliferation and Carcinoid Development: A Review of New Aspects of Hypergastrinaemic Atrophic Gastritis

Borch¹,

Renvall²,

Liedberg³

1986

Digestion

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The accumulating evidence of an association between antrum-sparing hypergastrinaemic atrophic gastritis, frequently associated with pernicious anaemia, and the occurrence of gastric carcinoid tumours is briefly reviewed. The development of argyrophil cell carcinoid tumours in the atrophic fundic mucosa seems to be related to argyrophil cell hyperplasia caused by hypergastrinaemia. Epidemiologic considerations indicate that the gastric carcinoid generally is underdiagnosed and that the incidence of this tumour is higher than previously recognized. The clinical relevance of minute gastric carcinoids, or endocrine cell ‘adenomas’, is obscure. However, larger tumours should be regarded as potentially malignant. These findings are relevant to the aspect of long-term medically induced achlorhydria leading to hypergastrinaemia.

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Immunological Aspects of Gastro-Intestinal Pathology

Cited by 7 publications

References 104 publications

Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

Changes in enzyme activity in normal and histologically inflamed oesophageal epithelium.

Endocrine Cell Proliferation and Carcinoid Development: A Review of New Aspects of Hypergastrinaemic Atrophic Gastritis

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