Immunological Aspects of Atheroma: A Review

Poston, Robin N.

doi:10.1177/014107687907200910

Cited by 13 publications

(4 citation statements)

References 63 publications

(37 reference statements)

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“…Clearly, therefore, other factors, e.g. environmental, genetic must be operative in this regard and indeed the pathogenesis of ischaemic heart disease itself is almost certainly heterogeneous and multi factorial (Gault and Gentzler l976;Poston 1979).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Glucose Uptake in Young Men with Myocardial Infarction

Ra¹,

Pm²,

Ja³

et al. 1983

Horm Metab Res

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Forearm glucose uptake (FGU) was studied during 100 g oral glucose tolerance tests (GTT) in nonobese, nondiabetic men who had suffered a myocardial infarction (MI) at or before the age of 40, and the results compared with the response in age-matched normal men. In the MI group the rise in both glucose and insulin concentrations after glucose loading was similar to that in normal subjects, although in the former, peak levels tended to be slightly higher. Concomitant FGU, however, was significantly greater in the MI group than in control subjects in the period 0-90 min and in the test as a whole (0-180 min). The results show that at least in some nondiabetics suffering MI at an early age hyperinsulinism is not a feature and peripheral tissue sensitivity is increased.

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Section: Discussionmentioning

confidence: 99%

Peripheral Glucose Uptake in Young Men with Myocardial Infarction

Ra¹,

Pm²,

Ja³

et al. 1983

Horm Metab Res

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show abstract

“…Endothelial injury can be produced by a variety of factors and may manifest itself in a spectrum of damage from subtle changes in permeability to complete desquamation. Amongst the many agents that have been shown experimentally to produce injury are mechanical damage, homocystinuria, immunological mechanisms, chronic hyperlipidaemia, endotoxins, viruses, certain products associated with tobacco smoking and haemodynamic forces (17,20,(23)(24)(25)(26)(27)(28)(29). Following endothelial injury, the platelets aggregate and release a number of chemical mediators, one of the most important being a mitogenic factor which has been identified and shown to cause edial myocyte migration and proliferation (30,31).…”

Section: S18mentioning

confidence: 99%

Can drugs help patients with lower limb ischaemia?

Boobis

Bell

1982

Journal of British Surgery

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The prevalence of symptomatic arterial disease of the lower limbs is 2 per cent of the population aged 45-60, but it has a relatively benign course, with 70 per cent of patients requiring no therapy. Of the numerous drugs used in the treatment of the disease, there is no evidence to suggest that antilipaemic drugs, anticoagulants, vasodilators or rheological agents confer any benefit to the patient. The initial use of antiplatelet drugs and prostaglandins has been disappointing despite the undoubted importance of the platelet/endothelial interaction in the aetiology of atherosclerosis. As it is unlikely that we can reverse advanced disease, this is hardly surprising. Long term use of these drugs may prevent deterioration in those patients with progressive disease, and controlled trials on this aspect of treatment are now required. Symptomatic relief in the claudicant may perhaps be obtained with naftidrofuryl and suloctodil and with the former in more severe ischaemia, but their use should not replace the beneficial effects of exercise and cessation of smoking.

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“…Their levels are too low to be detectable in the serum, even by immunofluorescence. 25 Hollander et a1.26 claimed that immunoglobulin eluted from atherosclerotic plaques bound specifically to sections of normal arterial wall. Mathews et all found an epidemiologic association between the presence of circulating autoantibodies and the occurrence of arterial disease or of cardiovascular mortality.…”

mentioning

confidence: 99%

Immunologic Aspects of Heart Disease

DeCarvalho

1982

Angiology

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All forms of heart disease, whether caused by streptococcus group A, aseptic heart injury, virus, hypersensitivity, autoimmune conditions, or graft-versus-host reactions, have in common allogenic transformation of the myocardial cell membrane and production of multifunctional autoantibodies, in addition to cause-specific antibodies, some of which cross-react with heart tissue. The outcome of this immunologic insult depends on the ability of the host's immunoregulatory mechanisms to dispose swiftly of the offending antigen and antibody or their complexes. Heart disease often results when these mechanisms, exemplified here, are not intact or when they function inappropriately in genetic or acquired settings and in varying haplotype frames.

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Immunological Aspects of Atheroma: A Review

Cited by 13 publications

References 63 publications

Peripheral Glucose Uptake in Young Men with Myocardial Infarction

Peripheral Glucose Uptake in Young Men with Myocardial Infarction

Can drugs help patients with lower limb ischaemia?

Immunologic Aspects of Heart Disease

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