Immunological aspects of additional revaccination of adolescents against whooping cough, diphtheria and tetanus

Abstract

The epidemiological situation of whooping cough in many countries of the world shows an increase in the incidence, despite the high coverage of routine immunization of the child population, which indicates the need for additional booster doses in older age groups. Purpose. The study aims at a comparative analysis of the intensity of specific immunity against whooping cough, diphtheria and tetanus in adolescent children after revaccination with different types of vaccines. Material and methods. 121 adolescents received various preparations containing pertussis, diphtheria and tetanus as revaccination. Results. The use of the pertussis component in preparations for revaccination of adolescents, despite the fact that they initially have a certain level of seroprotection, is not accompanied by a significant increase in specific antibody titers. Some differences related to the types of drugs used: the AbDTP-M vaccine against AbDTP had the best seroprotection after 1 month, while at the same time, as after 12 months, this ratio reversed. Conclusion. The situation with the effectiveness of revaccination against tetanus and diphtheria with all the drugs used had a more predictable effect, which was reflected in a significant increase in the titer of specific antibodies after 1 month.