Immunological Aspects

Horowitz, Mark

doi:10.1016/b978-0-12-356102-2.50017-2

Cited by 10 publications

(1 citation statement)

References 283 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other blood groups such as Lewis, Rh, MN, Ii are also based on the carbohydrate structures [54], Some examples of the Lewis antigens are also shown in figure 8.…”

Section: Gpi Anchormentioning

confidence: 99%

Glycobiology in Medicine

Lee¹,

Lee²

1996

J Biomed Sci

View full text Add to dashboard Cite

Glycoconjugates play important roles in biological reactions (for example sialyl Lewis^x in ‘homing’ of leukocytes and mannose-6-phosphate in targeting of lysosomal enzymes) and thus aberration in carbohydrate structures in glycoconjugates can lead to abnormal biological behaviors. In fact, glycoconjugates expressed on the surfaces of tumor and cancer cells are considerably different from those of the normal cells, at least quantitatively. There are many known carbohydrate-deficient glycoprotein syndromes. As recognition of carbohydrate groups is mostly performed by carbohydrate-binding proteins, aberration in these proteins also results in disease status (for example I-cell disease). Many pathogens use carbohydrates as recognition markers for invasion (examples are influenza virus and cholera toxin). The carbohydrate receptors in various organs can be used for targeting drugs, antibodies and even DNAs. Conjugation of polysaccharides derived from pathogenic micro-organisms with appropriate proteins provides effective vaccines against the micro-organisms.

show abstract

“…Other blood groups such as Lewis, Rh, MN, Ii are also based on the carbohydrate structures [54], Some examples of the Lewis antigens are also shown in figure 8.…”

Section: Gpi Anchormentioning

confidence: 99%

Glycobiology in Medicine

Lee¹,

Lee²

1996

J Biomed Sci

View full text Add to dashboard Cite

show abstract

Advances in Selective Chemical Syntheses of Complex Oligosaccharides

Paulsen

1982

Angew. Chem. Int. Ed. Engl.

1,010

343

View full text Add to dashboard Cite

A wide variety of complex oligosaccharides has now been made accessible as a result of methodological improvements in the sphere of chemical synthesis, which can be used for the study of conformations and interactions with protein-receptor molecules. Such work is of particular importance because the oligosaccharide chains of glycoproteins and glycolipids anchored to the plasma membrane are important in cell-cell interactions and are receptors for enzymes, hormones, proteins, and viruses ; furthermore, they determine the antigen properties of cells. The methods of synthesis available for the production of selective linkages in oligosaccharides are dealt with, particular attention being paid to conversion of saccharides into oligosaccharides, which are important from the biological point of view.

show abstract

Products from furans. VII. A General Route for the Synthesis of α‐(1,2‐cis) and β‐(1,2‐trans) Glycoconjugates via 1‐O‐Acyl and 1‐O‐Ethoxycarbonyl‐2‐azido‐2,3‐dideoxyglycopyranosides

Georgiadis¹,

Couladouros²

1991

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A methodology for the synthesis of 2,3,6‐trideoxy‐ and 2,3‐dideoxy‐2‐aminoglycosides is presented. 2,3‐Dideoxyhex‐2‐enopyranos‐4‐uloses (named also as 2H‐pyran‐3(6H)‐ones) were used for the synthesis of 1‐O‐acetyl, 1‐O‐ethyloxycarbonyl and 1‐S‐phenyl‐2,3,6‐trideoxy‐(or 2,3‐dideoxy)‐2‐azidoglycopyranosyl donors. Glycosidation of the above thio‐ethers with a variety of alcohols in the presence of N‐bromosuccinimide as activator yielded predominantly α‐glycosides, while acetates afforded β‐glycosides when TMSOTf was used as a promoter. The coupling of carbonates using tin tetrachloride or TMSOTf proved to be the most successful procedure, yielding the β‐glycoside as the predominant product. Thus, glycoconjugates of aminosugars, steroids and aminoacids have been synthesized.

show abstract

Immunological Aspects

Cited by 10 publications

References 283 publications

Glycobiology in Medicine

Glycobiology in Medicine

Advances in Selective Chemical Syntheses of Complex Oligosaccharides

Products from furans. VII. A General Route for the Synthesis of α‐(1,2‐cis) and β‐(1,2‐trans) Glycoconjugates via 1‐O‐Acyl and 1‐O‐Ethoxycarbonyl‐2‐azido‐2,3‐dideoxyglycopyranosides

Contact Info

Product

Resources

About