Immunological and vascular characteristics in cavernous sinus meningioma

Kosugi, Kenzo; Tamura, Ryota; Ohara, Kentaro; Morimoto, Yukina; Kuranari, Yuki; Oishi, Yumiko; Yoshida, Kazunari; Toda, Masahiro

doi:10.1016/j.jocn.2019.06.003

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Immunohistochemical staining was performed on 4-mm-thick sections of formalinfixed paraffin-embedded tissues. The following steps were performed as described previously (22,23). The primary antibodies were anti-Ki-67 antibody (1:200, M7240, Agilent DAKO, Santa Clara, CA, USA), anti-CD4 antibody (1:250, 1F6, Nichirei Biosciences, Inc., Tokyo, Japan), anti-CD8 antibody (1:200, ab17147, Abcam, Cambridge, UK), and anti-CD163 antibody (1:500, ab87099, Abcam).…”

Section: Histopathological Analysismentioning

confidence: 99%

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Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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BackgroundMeningiomas are the most common benign intracranial tumors. However, even WHO grade I meningiomas occasionally show local tumor recurrence. Prognostic factors for meningiomas have not been fully established. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic factor for several solid tumors. The prognostic value of NLR in meningiomas has been analyzed in few studies.Materials and MethodsThis retrospective study included 160 patients who underwent surgery for meningiomas between October 2010 and September 2017. We analyzed the associations between patients’ clinical data (sex, age, primary/recurrent, WHO grade, extent of removal, tumor location, peritumoral brain edema, and preoperative laboratory data) and clinical outcomes, including recurrence and progression-free survival (PFS).ResultsForty-four meningiomas recurred within the follow-up period of 3.8 years. WHO grade II, III, subtotal removal, history of recurrence, Ki-67 labeling index ≥3.0, and preoperative NLR value ≥2.6 were significantly associated with shorter PFS (P < 0.001, < 0.001, 0.002, < 0.001, and 0.015, respectively). Furthermore, NLR ≥ 2.6 was also significantly associated with shorter PFS in a subgroup analysis of WHO grade I meningiomas (P = 0.003). In univariate and multivariate analyses, NLR ≥2.6 remained as a significant predictive factor for shorter PFS in patients with meningioma (P = 0.014).ConclusionsNLR may be a cost-effective and novel preoperatively usable biomarker in patients with meningiomas.

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Section: Histopathological Analysismentioning

confidence: 99%

“…The cell counts were performed in regions of maximum immunoreactivity. For the assessment of neutrophils, and CD4, CD8, and CD163 + cells, the stained tissue sections were screened at ×4 magnification, and five hot spots were selected, as described previously (22,23). The cells were counted manually at ×40 magnification.…”

Section: Histopathological Analysismentioning

confidence: 99%

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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“…On follow-up serial annual MRI, complete response of the treated tumor was seen, along with complete regression of the untreated lesion. In this case, the abscopal effect could be postulated to be related to the atypical grade of the tumor, as higher-grade tumors might yield a stronger immune effect when exposed to radiation ( 10 ). Our case is the first one of presumed low-grade meningioma demonstrating a possible response via the abscopal effect after single-fraction stereotactic radiosurgery.…”

Section: Discussionmentioning

confidence: 99%

Abscopal effect leading to complete disappearance of extensive meningiomatosis after gamma knife radiosurgery: Case report

Aldakhil

Mathieu

2022

Front. Surg.

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Background and ImportanceThe abscopal effect is partial or complete tumor response in a separate site that was not the target of prior local treatment. There have been only 50 well-documented cases from 1960 to 2014. Our case is the first one of presumed low-grade meningioma demonstrating a possible response via the abscopal effect after single-fraction stereotactic radiosurgery.Clinical PresentationA case of a 70-years-old female with extensive intracranial meningiomatosis who had complete disappearance of all tumors after gamma knife radiosurgery targeting the right petroclival part of the tumor. She had complete resolution of her symptoms, which included hearing loss, headache, ataxia and dysphagia.ConclusionThe abscopal effect is an extremely rare phenomenon after local radiation therapy of a remote tumor. Our case demonstrates that this can occur in remote meningiomas after single fraction GKRS of a different tumor.

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“…In meningioma in particular, both higher grade lesions (WHO grade II or III) and convexity (vs. skull-base) lesions are known to contain a significantly greater intratumoral T-cell infiltrate (23, 24). The clinical and therapeutic implications of this recent finding are 2-fold: (1) Higher grade meningiomas are likely associated with greater local and systemic immune-suppression and tumor immune-escape, particularly grade III lesions which are distinctly associated with increased intratumoral and peripheral PD-L1 expression (23, 25).…”

Section: Discussionmentioning

confidence: 99%

Possible Abscopal Effect Observed in Frontal Meningioma After Localized IMRT on Posterior Meningioma Resection Cavity Without Adjuvant Immunotherapy

et al. 2019

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Background: Localized radiation therapy (RT) is known to infrequently cause off-target or “abscopal” effects at distant metastatic lesions. The mechanism through which abscopal effects occur remains unknown, but is thought to be caused by a humoral immune response to tumor-specific antigens generated by RT. Combination treatment regimens involving RT and immunotherapy to boost the humoral immune response have demonstrated synergistic effects in promoting and accelerating abscopal effects in metastatic cancer. Nevertheless, abscopal effects, particularly after RT alone, remain exceedingly rare.Case Presentation: We report the case of an 84-year-old man with an atypical meningioma, who demonstrated a radiographically significant response to an untreated second intracranial lesion, likely also a meningioma, after intensity-modulated radiation therapy (IMRT) to a separate, detatched resection cavity. Serial annual MRI imaging starting at 2- to 3.5-year (most recent) post-IMRT follow-up demonstrated a persistent decrease in both tumor size and surrounding edema in the untreated second lesion, suggestive of a possible abscopal effect.Conclusions: We describe here the first report of a potential abscopal effect in meningioma, summarize the limited literature on the topic of abscopal effects in cancer, and detail the existing hypothesis on how this phenomenon may occur and possibly relate to the development of future treatments for patients with metastatic disease.

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Immunological and vascular characteristics in cavernous sinus meningioma

Cited by 8 publications

References 26 publications

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Abscopal effect leading to complete disappearance of extensive meningiomatosis after gamma knife radiosurgery: Case report

Possible Abscopal Effect Observed in Frontal Meningioma After Localized IMRT on Posterior Meningioma Resection Cavity Without Adjuvant Immunotherapy

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