Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.

Dejani, Naiara Naiana; Souza, Laís Cristina de; Oliveira, Sandra Regina Pereira de; Neris, Débora Meira; Rodolpho, Joice Margareth de Almeida; Correia, Ricardo O.; Rodrigues, Vanderlei; Sacramento, Luís Vitor Silva do; Faccioli, Lúcia Helena; Afonso, Ana; Aníbal, Fernanda F.

doi:10.1016/j.imbio.2014.03.015

Cited by 16 publications

(27 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ovicidal activity was recognised for its essential oil (Sinthusiri & Soonwera 2014); immunomodulatory and antiparasitic effects on Schistosomiasis (Dejani et al 2014). Antimicrobial (Bouari et al 2014), antibiofilm and antifungal effects (Saharkhiz et al 2012) along with cytotoxic effect on cancer cells (Hussain et al 2010;Berdowska et al 2013) and anxiolytic (Kravchenko et al 2012) capacities were reported.…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

show abstract

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…This herb has antiviral (Herrmann and Kucera, 1967 ), antibacterial (Kizil et al, 2010 ), antifungal (Saharkhiz et al, 2012 ), and analgesic (Leslie, 1978 ) activity. The pharmacological activities of M. piperita L. includes antiparasitic effects (Naranjo et al, 2006 ; Dejani et al, 2014 ). Dejani et al ( 2014 ) showed that the ethanol extract of Mentha piperita L. has antiparasitic and immunomodulatory properties for the experimental infection with S. mansoni .…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection

et al. 2016

Self Cite

View full text Add to dashboard Cite

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological and histological parameters in mice infected with Schistosoma mansoni and treated with an herbal commercial medicine. This drug consists of menthol (30–55%) and menthone (14–32%). A 60 day treatment regimen with the herbal medicine decreased the number of S. mansoni eggs in the feces, liver, and intestine and reduced the number of hepatic granulomas. We observed a reduction of 84% in blood eosinophilia and a decrease in the IL-4 and IL-10 blood levels after treatment. Therefore, we propose that schistosomiasis treatment with this herbal medicine for 60 days has an immunomodulatory and anti-inflammatory action in this animal model for schistosomiasis thus contributing to the decrease in physio pathological effects caused by S. mansoni infection.

show abstract

“…Recently, in vitro studies for new active compounds against S. mansoni [14][15][16] showed that ROT, a monoterpene found in Mentha species, showed promising antischistosomal properties against adult schistosomes 17,27 .…”

Section: Discussionmentioning

confidence: 99%

“…In this context, the search for natural bioactive compounds against S. mansoni offers a potentially valuable approach 15,16 . Members of the plant family Lamiaceae have been widely studied as a source of secondary metabolites with biological activity 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural study of morphological changes in Schistosoma mansoni after in vitro exposure to the monoterpene rotundifolone

Rocha

Cavalcanti

Barbosa-Filho

et al. 2017

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. Methods: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms. Results: At concentrations of 3.54 and 7.09μg/mL -1 rotundifolone, no worm mortality was observed at any of the sampling intervals. A minor reduction in movement of the tail, suckers, and gynecophoral canal membrane was observed after 96 h of exposure to 7.09μg/mL -1 rotundifolone. At 70.96μg/mL -1 , a lack of movement was observed from 72h onwards and all worms were deemed dead; similar effects were observed at 48h with 177.4μg/mL -1 , and at 24h with 354.8μg/mL -1 and 700.96μg/mL -1 . Rotundifolone also caused death of all parasites and separation of coupled pairs into individual males and females after 24h at 354.8μg/mL -1 . Conclusions: The main changes in the tegument induced by the different ROT treatments were: after 24h incubation, bubble lesions spread over the entire body and loss of tubercles occurred in some regions of the ventral region.

show abstract

Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.

Cited by 16 publications

References 40 publications

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection

Ultrastructural study of morphological changes in Schistosoma mansoni after in vitro exposure to the monoterpene rotundifolone

Contact Info

Product

Resources

About