Immunological and Molecular Characterization of an Idiotypic Cascade Specific for the Human Carcinoembryonic Antigen

Neumaier, Michael; Gaida, Franz-Josef; Pieper, Dagmar; Sherman, Mark A.; Shively, John E.

doi:10.1016/b978-044482807-1/50044-2

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Tisse-specific Expression Of Human Cea In Transgenic Mice1

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“…The human/mouse chim eric MAb cT84.66 [9], which is specific for CEA was used to detect CEA. The use of a chimeric MAb had the advantage that no unspecific staining occurred as with a mouse MAb in mouse tissue.…”

Section: Tisse-specific Expression Of Human Cea In Transgenic Micementioning

confidence: 99%

Carcinoembryonic Antigen-Transgenic Mice: A Model for Tumor Immunotherapy

Eades‐Perner

Zimmermann²

1995

Tumor Biol

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The tumor marker carcinoembryonic antigen (CEA) is a 180-kD glycoprotein expressed on epithelial cells of the gastrointestinal tract and respiratory organs. It is a member of a large family belonging to the immunoglobulin superfamily. In order to develop a mouse model to study tumor immunotherapy using CEA as a target antigen, we have established mice which are transgenic for the CEA gene. The human CEA transgene maintains its spatiotemporal expression pattern in transgenic mice thus providing a suitable model in which to optimize different immunotherapy approaches, with the advantage that negative side effects due to the presence of CEA in normal tissue can be analyzed.

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Section: Tisse-specific Expression Of Human Cea In Transgenic Micementioning

confidence: 99%