Immunological and genetic requirements for the parental hemopoietic takeover reaction in adult,H-2-incompatible parent-F1 hybrid parabiosis

Drell, Daniel; Wegmann, T

doi:10.1007/bf01561432

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Although differences in the GVHR-inducing capacities of different inbred mouse strains have previously been reported (5,7,15,16), the present data represent the first…”

Section: Discussionmentioning

confidence: 44%

“…This observation is consistent with the demonstration that the quality of the intestinal microflora exerts a tremendous influence on the mortality rate of mice undergoing GVHR (17). A rather poor capability of strain DBA/2 to induce lethal GVHD has also been described in studies with parabiotic mice where a better survival was found in parabionts made between strains DBA/2 and, for instance, (DBA/2 × CBA)Fx than in parabionts made between BALB/c and (BALB/c × CBA)F1 (15,18). However, this experimental design did not allow a comparison of the different parental strains in groups of genetically identical Fa hybrids.…”

Section: Taale VI T Lymphocytes Of the C57bl/10 Donor Are Required Fomentioning

confidence: 78%

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Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

Elven¹,

Rolink²,

Veen³

et al. 1981

The Journal of Experimental Medicine

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When comparing, in a murine model, the kind of graft-versus-host (GVH) disease (GVHD) induced by the donor strain DBA/2 on the one hand and several H-2-congenic resistant B10 donor strains on the other, we found that strain DBA/2 was a universal nonkilling GVH donor for H-2-incompatible nonirradiated F1 hybrid recipients. In this respect, DBA/2 T cells differed from those of the H-2-identical donor strain B10.D2 as well as those of other b10 donor strains. The inability of strain DBA/2 to kill by GVH reaction was not limited to certain H-2 incompatibilities in the F1 recipients, but was nonspecific. The inability to kill is determined by a dominant locus not linked to H-2. DBA/2 T cells were also incapable of inducing the severe suppression of hematocrit values, bone marrow erythropoiesis, thymic cell proliferation, and splenic IgG production in the F1 recipients that was observed after the injection of T cell from the B10 strains. However, DBA/2 T cells, in contrast with those of the B10 donor strains, were vigorous stimulators of IgG production in H-2-incompatible F1 hybrid recipients. Surprisingly, strain DBA/2 as well as the B10 donor strains had good capacity to generate anti-F1 TK cells. Taken together, these findings raise the possibility that lethal GVHD disease is not caused, or not caused exclusively, by donor killer T cells, but by those donor T cells that directly or indirectly induce a suppression of cell proliferation in certain vital organs of the recipient.

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“…Although differences in the GVHR-inducing capacities of different inbred mouse strains have previously been reported (5,7,15,16), the present data represent the first…”

Section: Discussionmentioning

confidence: 44%

Section: Taale VI T Lymphocytes Of the C57bl/10 Donor Are Required Fomentioning

confidence: 78%

Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

Elven¹,

Rolink²,

Veen³

et al. 1981

The Journal of Experimental Medicine

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The early ontogeny of hematopoietic cells studied by grafting cytogenetically labeled tissue anlagen: Localization of a prospective stem cell compartment

Turpen

Knudson

Hoefen

1981

Developmental Biology

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Immunological and genetic requirements for the parental hemopoietic takeover reaction in adult,H-2-incompatible parent-F1 hybrid parabiosis

Cited by 2 publications

References 25 publications

Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

The early ontogeny of hematopoietic cells studied by grafting cytogenetically labeled tissue anlagen: Localization of a prospective stem cell compartment

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