Immunological alterations in uncomplicated Plasmodium falciparum malaria. Relationship between parasitaemia and indicators of macrophage activation

Kremsner, Peter G.; Feldmeier, Hermann; Zotter, Gertraud M.; Jansen-Rosseck, Rolf; Graninger, Wolfgang; Rocha, Roraima M.; Bienzle, Ulrich

doi:10.1016/0001-706x(89)90047-8

Cited by 21 publications

(8 citation statements)

References 23 publications

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“…Treatment of malaria presumably might have also directly improved cellmediated immunity because malaria produces a pronounced de®cit of cell-mediated immunity in humans (Walsh et al, 1995) and in animals (Yadav, 1989). Plasmodium falciparum malaria is associated with a de®cit of helper-inducer T cells (Peyron et al, 1989;Kremsner et al, 1989), whereas suppressor-cytotoxic T cells are reported to be decreased (Chougnet et al, 1990) or normal (Kremsner et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children

Berger

Dyck²,

Galán³

et al. 2000

Eur J Clin Nutr

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Objective: To assess the impact of a daily oral iron supplementation on hematological status, cell-mediated immunity and susceptibility to infections in children living in an environment where iron de®ciency, malaria and other infections are frequent. Design: Randomized, double-blind iron supplementation including a placebo group. Setting: A village in Togo, West Africa. Subjects: Of the 229 6 ± 36-month-old children of both sexes recruited, 197 with hemoglobin concentration ! 80 gal were included and 163 completed the study. Intervention: Children received daily a placebo (n 79) or a dose of 2 ± 3 mg of elemental iron per kg of body weight (n 84) for 3 months. Hematological, nutritional and immune status were assessed at the beginning and at the end of the supplementation period, and 6 months later. Morbidity was recorded throughout the study. Results: Iron supplementation had a signi®cant and positive effect on iron status of children and no impact on the incidence of infections, especially malaria. Its probable effect on immune status was masked by interference of infections and their treatment, which contributed to improve hematological and immune status in both groups. Conclusion: According to the negative consequences of anemia and iron de®ciency on global child development, control of iron de®ciency by oral iron supplementation in young children has to be conducted, associated with prophylaxis and treatment of malaria and repeated deworming.

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Section: Discussionmentioning

confidence: 99%

Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children

Berger

Dyck²,

Galán³

et al. 2000

Eur J Clin Nutr

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“…The production of cytokines such as tumor necrosis factor (TNF) and interleukin-6 (IL-6) has been found to play a role in protection against malaria parasites and also in the pathology of human malarial disease (5,(8)(9)(10)(11)(12)(13)16). The production of high concentrations of TNF by human and murine macrophages as a response to malaria antigens has also been reported previously (2,3,13,20,(23)(24)(25).…”

mentioning

confidence: 86%

Production of interleukin-6 by human and murine mononuclear leukocytes stimulated with Plasmodium antigens is enhanced by pentoxifylline, and tumor necrosis factor secretion is reduced

Prada¹,

Prager²,

Neifer³

et al. 1993

Infect Immun

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When pentoxifylline was present during stimulation of human mononuclear leukocytes with Plasmodium falciparum exogenous antigens, an increase in interleukin-6 production was observed simultaneously with a reduction of tumor necrosis factor secretion. Similar results were obtained in murine macrophages stimulated with P. vinckei antigens. This indicates the independence of interleukin-6 and tumor necrosis factor secretion in response to malaria antigens.

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“…An increase of IFN-3' concentrations in serum of patients infected with P.falciparum was reported in some [38][39][40][41][42], but not in other studies [43][44][45], which may depend on different detection limits of IFN-3' in the test systems used. The levels of IFN-3' in serum of acutely infected individuals depended strongly on their immune status: non-immune individuals have a high peak of IFN-3' in serum during the malaria attack compared to semiimmune subjects who do not have significant changes in their IFN-3' serum levels [41,42].…”

Section: Cells and Cytokines In The Pathogenesis Of Cerebral Malaria mentioning

confidence: 97%

“…The level of both these cytokines is elevated during malaria infection [38][39][40][41][42][43][44][45][46][47][48][49][50]. Recently, it was shown that ICAM-1 is shed from the surface of cells into the plasma.…”

Section: Icam-1 Sequestration and Cytokinesmentioning

confidence: 99%

Cytokines in malaria, pathology and protection

Eling

Kremsner

1994

Biotherapy

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Immunological alterations in uncomplicated Plasmodium falciparum malaria. Relationship between parasitaemia and indicators of macrophage activation

Cited by 21 publications

References 23 publications

Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children

Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children

Production of interleukin-6 by human and murine mononuclear leukocytes stimulated with Plasmodium antigens is enhanced by pentoxifylline, and tumor necrosis factor secretion is reduced

Cytokines in malaria, pathology and protection

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