Immunological Alterations in the Lungs of Mice following Ozone Exposure: Changes in Immunoglobulin Levels and Antibody-Containing Cells

Osebold, John W.; Owens, Sally; Zee, Y. C.; Dotson, William M.; LaBarre, David D.

doi:10.1080/00039896.1979.10667411

Cited by 36 publications

(20 citation statements)

References 15 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IgG-and IgM-secreting cells in murine bronchus-associated lymphoid tissue (BALT) (9) and B-cell numbers in the lung as a whole did not change with prolonged 03 exposures (7). Likewise, exposure of rats to 0.13 ppm 03 for 1 week increased T/B cell ratios in the MLN, with the increases lasting for at least 5 days after cessation of exposure (10).…”

Section: Environmental Health Perspectivesmentioning

confidence: 96%

The Effects of Ozone on Immune Function

Jakab¹,

Spannhake²,

Canning³

et al. 1995

Environmental Health Perspectives

View full text Add to dashboard Cite

A review of the literature reveals that ozone (03) exposure can either suppress or enhance immune responsiveness. These disparate effects elicited by 0 exposure depend, in large part, on the experimental design used, the immune parameters examined as well as the animal species studied.Despite the apparent contradictions, a general pattern of response to 03 exposure can be recognized. Most studies indicate that continuous 03 exposure leads to an early (days 0-3) impairment of immune responsiveness followed, with continued exposures, by a form of adaptation to 03 that results in a re-establishment of the immune response. The effects of 03 exposure on the response to antigenic stimulation also depend on the time at which 03 exposure occurred. Whereas 03 exposure prior to immunization is without effect on the response to antigen, 03 exposure subsequent to immunization suppresses the response to antigen. Although most studies have focused on immune responses in the lung, numerous investigators have provided functional and anatomical evidence to support the hypothesis that 03 exposure can have profound effects on systemic immunity. -Environ Health Perspect 1 03(Suppl 2): 77-89 (1995)

show abstract

Section: Environmental Health Perspectivesmentioning

confidence: 96%

The Effects of Ozone on Immune Function

Jakab¹,

Spannhake²,

Canning³

et al. 1995

Environmental Health Perspectives

View full text Add to dashboard Cite

show abstract

Section: Defence Against Infectionsmentioning

confidence: 99%

“…It has also been reported that O 3 and NO 2 exposure can alter the pattern of the immunological response [136,[143][144][145][146][147]. An increased level of immunoglobulins in lung lavage fluid has been reported in mice after exposure to O 3 [143]. In guinea-pigs, the appearance of serum antibody to normal lung tissue relates to the amount and duration of exposure to NO 2 , possibly as a consequence of an auto-antigenic effect of altered components of the lung tissue [144].…”

Section: Defence Against Infectionsmentioning

confidence: 99%

Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research

Chitano¹,

Hosselet²,

Mapp³

et al. 1995

Eur Respir J

View full text Add to dashboard Cite

In the present paper, we have reviewed experimental animal studies on the effects of the two most important oxidant airborne pollutants, nitrogen dioxide and ozone, on the respiratory system.The toxic effects depend on concentration and length of exposure, and are generally similar for both oxidants, with ozone operative at lower concentrations. High doses of both oxidants cause death due to lung oedema Exposure to sublethal levels causes functional alterations such as airflow limitation and airway hyperresponsiveness to bronchoconstrictor stimuli. These effects, which are generally reversible, are associated with epithelial injury, oedema and airway and parenchymal infiltration by inflammatory cells. Loss of cilia of airway epithelium and necrosis of type I alveolar epithelial cells are the most prominent consequences at the epithelial level. Inmation is characterized by early neutrophilic infiltration, followed by an increased number of mononuclear cells, predominantly alveolar macrophages.After long-term exposure, whilst nitrogen dioxide causes predominantly emphysema, ozone produces mainly pulmonary fibrosis. Biochemical effects include lipid peroxidation, increased antioxidant metabolism, and alteration of enzyme activity. Nitrogen dioxide and ozone may also alter the immunological response and reduce the defence against infections, increasing the susceptibility of exposed animals to infections.

show abstract

“…Our previous work had shown that damage to respiratory mem branes could be monitored by quantitating the serum albumin levels in respiratory se cretions [3]. On day 4 of ozone exposure a peak of serum albumin in secretions sug gested that this was a period of impaired membrane integrity, and a time when ex trinsic antigen might easily gain access to immunocompetent cells in the mesenchymal tissues underlying the epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Osebold et al [3] found that ozone in concentrations that are achieved in high air pollution episodes can effect changes in the lungs of mice, including immunological re sponsiveness. Oxidant damage by ozone was accompanied by increases of IgA-containing cells in the lungs and rises in the IgA content of respiratory secretions.…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin E-Containing Cells in Mouse Lung Following Allergen Inhalation and Ozone Exposure

Gershwin

Osebold

Zee

1981

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Cells containing immunoglobulin E (IgE) were enumerated and their location in mouse lungs was determined by direct immunofluorescence. Lungs were studied from mice that had been immunized with aerosolized ovalbumin as well as from normal mice and from mice that were exposed to ozone (0.5 or 0.8 ppm) prior to receiving aerosolized antigen. In addition, some mice were immunized intraperitoneally with ovalbumin precipitated in alum. IgE-containing cells were primarily airway-related in normal mice and in mice immunized by the intraperitoneal route. Lungs from aerosol-immunized, and aerosol-immunized and ozone-exposed mice showed a more disseminated distribution of IgE-containing cells. Fluorescent cells were counted and numbers were expressed as total cells per square millimeter of lung tissue and as airway-associated cells per millimeter of airway. Total IgE cells increased 9.4-fold in mice that received aerosolized ovalbumin as compared to normal mice. When ozone exposure was added to the effects from aerosolized ovalbumin, the increase of IgE cells over normal was 34.2-fold. IgE cell counts correlated well with anaphylactic sensitivity to intravenous challenge with ovalbumin. The observed enhancement of allergic sensitization by ozone exposure has important implications for human health.

show abstract

Immunological Alterations in the Lungs of Mice following Ozone Exposure: Changes in Immunoglobulin Levels and Antibody-Containing Cells

Cited by 36 publications

References 15 publications

The Effects of Ozone on Immune Function

The Effects of Ozone on Immune Function

Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research

Immunoglobulin E-Containing Cells in Mouse Lung Following Allergen Inhalation and Ozone Exposure

Contact Info

Product

Resources

About