Immunological alterations in adult obsessive-compulsive disorder

Marazziti, Donatella; Presta, S.; Pfanner, Chiara; Gemignani, A.; Rossi, Alessandra; Sbrana, Silverio; Rocchi, Valeria; Ambrogi, F; Cassano, Giovanni Battista

doi:10.1016/s0006-3223(98)00371-0

Cited by 44 publications

(17 citation statements)

References 36 publications

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“…Early studies on adult patients suffering from anxiety and obsessive-compulsive disorders have demonstrated immunological alterations including a significant increase of CD8 + and decrease of CD4 + lymphocytes compared with the healthy control group. 30 The same abnormality has been observed in patients with autism, a disorder characterized also by obsessive-compulsive symptoms and anxiety disorders. 31 A recent study has also demonstrated in a quantitative manner an inverse relationship between CD4 count and hospital-associated anxiety and depression.…”

Section: Discussionmentioning

confidence: 59%

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

et al. 2013

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An imbalanced immune system has long been known to influence a variety of mood disorders including anxiety, obsessive-compulsive disorders and depression. In this study, we sought to model the impact of an immunocompromised state on these emotional behaviors using RAG-1−/− mice, which lack T and B cells. We also investigated the relative contribution of CD4+ or CD8+ T cells to these manifestations using RAG-1−/−/OT-II and RAG-1−/−/OT-I transgenic mice, respectively. Our results show that RAG-1−/− mice present a significant increase in digging and marble-burying activities compared with wild-type mice. Surprisingly, these anxiety-like behaviors were significantly reverted in RAG-1−/−/OT-II but not RAG-1−/−/OT-I transgenic mice. Immunodepletion experiments with anti-CD4 or anti-CD8 in C57/BL6 mice or repopulation studies in RAG-1−/− mice did not reproduce these findings. Microarray analysis of the brain of RAG-1−/− and RAG-1−/−/OT-II mice revealed a significantly different gene fingerprint, with the latter being more similar to wild-type mice than the former. Further analysis revealed nine main signaling pathways as being significantly modulated in RAG-1−/− compared with wild-type mice. Taken together, these results suggest that life-long rather than transient immunodeficient conditions influence the emotional behaviors in mice. Most interestingly, these effects seem to correlate with a specific absence of CD4+ rather than CD8+ T cells. Validation of these findings in man might provide new clues on the mechanism by which early life immune modulation might impact mood response in adults and provide a further link between immune and emotional well-being.

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Section: Discussionmentioning

confidence: 59%

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

et al. 2013

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“…These data are supported also by the observation of increased CD8+ (suppressor) lymphocytes and decreased CD4+ (T helper) lymphocytes in adult OCD patients, as compared with healthy controls [47]. Unfortunately, no information regarding children is currently available.…”

Section: Pathophysiologymentioning

confidence: 75%

Obsessive-Compulsive Disorder in Childhood and Adolescence

Presta¹,

Marazziti²,

Dell’Osso³

et al. 2003

Psychopathology

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Obsessive-compulsive disorder (OCD) is a common psychiatric condition during childhood and adolescence, which continues to be underestimated and undertreated. For these reasons, it constitutes a primary cause of major disabilities in those ages and, sometimes, of permanent impairments later on. In these last few years, childhood and adolescence OCD has attracted an increasing focus which has promoted a deeper awareness of this illness, a better recognition with earlier interventions, as well as the set-up of more tailored and specific strategies, including psychotropic drugs. The aim of this paper is to present a critical review of paediatric OCD, with a special attention towards the most compelling reports available up to now and towards the most interesting areas for future research.

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“…Marazziti et al [48,49] reported that OCD patients showed a significant increase of CD8+ and decrease of CD4+ T lymphocytes when compared with controls. Interestingly, these immunophenotypic changes were reverted by treatment with selective serotonin reuptake inhibitors, in parallel with clinical improvement [48].…”

Section: Changes In Immune Parameters In Ocdmentioning

confidence: 99%

Searching for the Immune Basis of Obsessive-Compulsive Disorder

Teixeira¹,

Rodrigues²,

Marques

et al. 2014

Neuroimmunomodulation

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The etiopathogenesis of obsessive-compulsive disorder (OCD) remains elusive. Clinical observation of the elevated frequency of obsessive-compulsive symptoms in patients with rheumatic fever, a post-streptococcal autoimmune disease, prompted the study of immune parameters in OCD. Anti-basal ganglia antibodies have been described in a subset of OCD patients. The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD. Several factors, including the use of psychotropic drugs and the presence of comorbid conditions, seem to influence these immune parameters.

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Immunological alterations in adult obsessive-compulsive disorder

Cited by 44 publications

References 36 publications

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

Obsessive-Compulsive Disorder in Childhood and Adolescence

Searching for the Immune Basis of Obsessive-Compulsive Disorder

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