Immunologic variables in acute mania of bipolar disorder

Liu, Hsing Cheng; Yang, Yi Yuan; Chou, Yech Mei; Chen, Kun Po; Shen, Winston W.; Leu, Sy Jye

doi:10.1016/j.jneuroim.2004.01.006

Cited by 108 publications

(79 citation statements)

References 62 publications

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“…139 Clinical studies suggest that immune function is altered in bipolar disorder patients, and that they may be in a proinflammatory state, but much work remains before this is implicated as a causal factor. [140][141][142] Thus far, factors known to increase the turnover of AA within brain phospholipids of the unanesthetized rat have not been extensively studied. If reliable rodent models of bipolar disorder are developed, it would be useful to test if they are associated with increased AA turnover and AA incorporation into brain phospholipids using quantitative autoradiography and/or chemical analysis.…”

Section: Observations Related To Aa In Bipolar Disorder Patientsmentioning

confidence: 99%

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

et al. 2008

Mol Psychiatry

108

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Bipolar disorder is a major medical, social and economic burden worldwide. However, the mechanisms of action of effective antibipolar disorder drugs remain elusive. In this paper, we review studies using a neuropharmacological approach in unanesthetized rats, combined with kinetic, biochemical and molecular biology techniques, showing that chronic administration of three Food and Drug Administration-approved mood stabilizers (lithium, valproate and carbamazepine) at therapeutically relevant doses, selectively target the brain arachidonic acid (AA) cascade. Whereas chronic lithium and carbamazepine decrease the binding activity of activator protein-2 and in turn the transcription, translation and activity of its AA-selective calcium-dependent phospholipase A 2 gene product, valproate appears to be a non-competitive inhibitor of long-chain acyl-CoA synthetase. The net overlapping effects of the three drugs are decreased turnover of AA but not of docosahexaenoic acid in rat brain phospholipids, and decreased brain cyclooxygenase-2 and prostaglandin E 2 . Although these observations support the hypothesis proposed by Rapoport and colleagues that the AA cascade is a common target of mood stabilizers, this hypothesis is not necessarily exclusive of other targets. Targeting the AA cascade with drugs or diet may be a useful therapeutic approach in bipolar disorder, and examining the AA cascade in patients might help in better understanding the disease.

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Section: Observations Related To Aa In Bipolar Disorder Patientsmentioning

confidence: 99%

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

et al. 2008

Mol Psychiatry

108

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“…Additionally, IL-6, TNF-α, and soluble IL-2 receptor were reported to be significantly increased in manic episodes compared to healthy controls [5,7]. On the other hand, Liu et al [18] found no relationship between manic patients and healthy controls regarding serum IL-2 levels. In a study by Cunha et al [12], it was reported that serum high-sensitive C-reactive protein (hsCRP) was increased in manic patients compared to euthymic and healthy controls.…”

Section: Discussionmentioning

confidence: 98%

“…The biological mechanisms of BD still remain unclear, but it can be effectively conceptualized as a multi-systemic inflammatory disease [3]. To date, changes in peripheral inflammatory markers have been reported in BD such as cytokine profiles [4][5][6][7][8][9][10][11], acute phase proteins [12][13][14], and lymphocyte cell activation [5,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Ayhan¹,

Çiçek²,

İnanlı³

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD. ARTICLE HISTORY

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“…Segundo revisão da literatura, os estudos que avaliaram esses fatores antes do uso de medicamentos não apresentaram, em sua maioria, alterações dos parâmetros imunes, sugerindo que as alterações imunológicas seriam intrínsecas ao TB 27,28,[30][31][32]39,[40][41][42] . Entretanto, Padmos et al 21 …”

Section: Discussionunclassified

Imunologia do transtorno bipolar

Barbosa

Huguet²,

Neves

et al. 2009

J. bras. psiquiatr.

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Palavras-chaveTranstorno bipolar, imunologia, citocinas, quimiocinas, interleucinas, interferon e fator de necrose tumoral-α. rEsumo objetivo: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. métodos: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. As bases de dados avaliadas foram MedLine e Scopus, entre os anos de 1980 e 2008. resultados: Foram identificados 28 trabalhos que estudaram alterações imunes em pacientes com transtorno bipolar. Seis artigos investigaram genes relacionados à resposta imune; cinco, autoanticorpos; quatro, populações leucocitárias; 13, citocinas e/ou moléculas relacionadas à resposta imune e seis, leucócitos de pacientes in vitro. Conclusões: Embora haja evidências na literatura correlacionando o transtorno bipolar a alterações imunes, os dados não são conclusivos. O transtorno bipolar parece estar associado a níveis mais elevados de autoanticorpos circulantes, assim como à tendência à ativação imune com produção de citocinas pró-inflamatórias e redução de parâmetros anti-inflamatórios. aBstraCt Objective: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. Methods:Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor

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Immunologic variables in acute mania of bipolar disorder

Cited by 108 publications

References 62 publications

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Imunologia do transtorno bipolar

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