Immunologic studies of experimental beryllium lung disease in the guinea pig

Barna, Barbara P.; Chiang, Theresa; Pillarisetti, Sudha G.; Deodhar, Sharad D.

doi:10.1016/0090-1229(81)90150-1

Cited by 24 publications

(13 citation statements)

References 10 publications

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“…Endotracheal administration of 5 mg BeO (Brush Wellman, Cleveland, Ohio) in 1.0 ml sterile physiological saline was per formed as previously described (6). As controls, some animals re ceived intratracheal injections of 1.0 ml of a 1:20 dilution of latex particles (0.81 urn, Dil'co, Detroit, Mich.) in saline.…”

Section: Induction O F Lung Diseasementioning

confidence: 99%

“…Samples of lung tissue were removed for histologic ex amination and analysis of beryllium and hydroxyproline content. Severity of granulomatous involvement and interstitial infiltrate in lung tissue was graded as previously described from 0 (normal) to 4+ (> 5 granulomas/low power field) [6]. Presence of fibrosis was determined histologically using Masson trichrome stain.…”

Section: Induction O F Lung Diseasementioning

confidence: 99%

“…At 6 weeks, half the animals were killed, and lymph nodes and spleens removed for in vitro studies. Others were skin tested as previously described [6], using 5 ug beryl lium sulfate (BeSO., • 4H:0 ) (Brush Wellman), saline, 5 ,ug magne sium sulfate (MgSOj • 7H:0 ) (Fisher, Fairlawn. N.J.), or a 1:5 dilu tion of second strength PPD (Connaught Laboratories, Ont., Cana da).…”

Section: Immunization Schedules and Skin Testsmentioning

confidence: 99%

“…and 50 ug/ml gentamycin (Schering, Kenilworth, N.J.). 500,000 cells were plated in each well of a microtiter tray (Falcon Products, Oxnard, Calif.) and a lymphocyte transformation assay carried oul as described previously [6]. A nti gens included BeS04, MgS04, and nickel sulfate (N iS04; Fisher) at 10 and 1.0 ng/ml, and BeO and nickel oxide (NiO; Aldrich Chemi cal Co., Milwaukee, Wise.)…”

Section: Antibody Studiesmentioning

confidence: 99%

“…those seen in chronic berylliosis in man [6]. Inbred strain 2 guinea pigs exposed to beryllium oxide (BeO) also developed granulomatous lung disease, but strain 13 animals did not.…”

Section: Introductionmentioning

confidence: 99%

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Experimental Beryllium-Induced Lung Disease

Barna

Deodhar

Chiang

et al. 1984

Int Arch Allergy Immunol

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Granulomatous lung disease was produced in strain 2 but not strain 13 guinea pigs by endotracheal injection of beryllium oxide (BeO), although isolated multinucleated giant cells containing crystalline material were found in lungs of both strains. Disease was also produced in (2 × 13) F₁ hybrids, but of a milder form than in strain 2. In BeO-treated strain 2 and F₁ animals, challenge with beryllium salts produced delayed hypersensitivity skin reactivity, and in vitro, enhanced tritiated thymidine uptake and lymphokine production by lymph node cells. No evidence was found for involvement of humoral immunity in the disease. Responses were not seen in BeO-treated strain 13 guinea pigs, and immunization of animals with BeO in complete Freund’s adjuvant produced similar immunologic findings. These data emphasize the involvement of genetically determined cellular immune mechanisms in beryllium lung disease.

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Section: Induction O F Lung Diseasementioning

confidence: 99%

Section: Induction O F Lung Diseasementioning

confidence: 99%

Section: Immunization Schedules and Skin Testsmentioning

confidence: 99%

Section: Antibody Studiesmentioning

confidence: 99%

“…those seen in chronic berylliosis in man [6]. Inbred strain 2 guinea pigs exposed to beryllium oxide (BeO) also developed granulomatous lung disease, but strain 13 animals did not.…”

Section: Introductionmentioning

confidence: 99%

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Experimental Beryllium-Induced Lung Disease

Barna

Deodhar

Chiang

et al. 1984

Int Arch Allergy Immunol

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Beryllium

Rossman

Wambach²,

Ziegler‐Skylakakis

et al. 2023

Patty's Toxicology

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Beryllium, found in a variety of different forms, has become indispensable in modern high‐technology industries, especially aerospace. It has many attractive properties, including light weight, high strength, and heat resistance. Unfortunately, beryllium is associated with a number of toxic effects. Even under controlled conditions, beryllium metal, oxide, and alloys can cause chronic lung disease among individuals exposed to dust or fume. Identifying properties of different forms of beryllium are described in Section followed by sections which describe the properties and characteristics of beryllium. These include production and use, toxic effects, standards, and exposure assessment.

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Beryllium

Mroz¹,

Balkissoon²,

Newman³

2001

Patty's Toxicology

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Beryllium, found in a variety of different forms, has become indispensable in modern high‐technology industries, especially aerospace. It has many attractive properties, including light weight, high strength, and heat resistance. Unfortunately, beryllium is associated with a number of toxic effects. Even under controlled conditions, beryllium metal, oxide, and alloys can cause chronic lung disease among individuals exposed to dust or fume. Identifying properties of different forms of beryllium are listed in Sections the first followed by sections, which describe the properties and characteristics of beryllium per se. These include production and use, toxic effects, standard and exposure assessment.

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Immunologic studies of experimental beryllium lung disease in the guinea pig

Cited by 24 publications

References 10 publications

Experimental Beryllium-Induced Lung Disease

Experimental Beryllium-Induced Lung Disease

Beryllium

Beryllium

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