Immunologic Studies in Presumed Amniotic Fluid Embolism

Benson, Michael D.; Kobayashi, Hiroshi; Silver, Richard K.; Oi, Hidekazu; Greenberger, Paul A.; Terao, Toshihiko

doi:10.1097/00006250-200104000-00006

Cited by 41 publications

(61 citation statements)

References 18 publications

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“…6,7 The clinical scenario we describe in our report ts well with the presumptive diagnosis, namely peripartum acute collapse with cardiac arrest, hypoxia, neurological signs and coagulopathy, 8 and as such we made the diagnosis on clinical grounds. Laboratory investigations that served to con rm the diagnosis included the deranged INR and the low complement levels.…”

Section: Discussionsupporting

confidence: 64%

Amniotic fluid embolism in an HIV-positive parturient

Penfold

Corbett

Bortolan

2010

Southern African Journal of Anaesthesia and Analgesia

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Section: Discussionsupporting

confidence: 64%

Amniotic fluid embolism in an HIV-positive parturient

Penfold

Corbett

Bortolan

2010

Southern African Journal of Anaesthesia and Analgesia

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“…A numerical increase of pulmonary mast cells is seen in subjects who died of AFE, with values that correspond to those encountered in deaths due to anaphylaxis [101]. Serum tryptase and urinary histamine measurements were negative in another series but most women with AFE had elevated levels of fetal antigen [104].…”

Section: Pathophysiologymentioning

confidence: 57%

Nonthrombotic pulmonary embolism

Jorens¹,

Marck²,

Snoeckx³

et al. 2009

European Respiratory Journal

161

127

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Nonthrombotic pulmonary embolism (NTPE) is defined as embolisation to the pulmonary circulation of different cell types (adipocytes, haematopoietic, amniotic, trophoblastic or tumour), bacteria, fungi, foreign material or gas. The purpose of this article is to describe the clinical signs, pathogenesis, diagnosis and treatment of the different NTPE subtypes.The complex and diverse pathogenesis of different subtypes of emboli is subject to continuing speculation and is certainly far more complex than ''simple'' mechanical obstruction after embolisation of vascular thrombi. Nonthrombotic emboli may also lead to a severe inflammatory reaction both in the systemic and pulmonary circulation, as well as in the lung.NTPE presents a formidable diagnostic challenge, as the condition often presents with very unusual and peculiar clinical signs that are frequently overlooked. They range from very dramatic acute presentations such as acute respiratory distress syndrome to signs observed late in the disease course. Pathological observations play a key role in the exact diagnosis, and sometimes carefully aspirated blood from the pulmonary artery or specific staining of cells recovered from bronchoalveolar lavage fluid may be helpful. Frequently, lung biopsies revealing severe granulomatous reaction or unfortunate post-mortem pathological investigations of pulmonary tissue are necessary to confirm the diagnosis. Here, we also aim to familiarise the reader with the atypical radiological features of NTPE. Thin-section computed tomography of the lungs showing peculiar radiographic findings, such as a feeding vessel, the so-called tree-in-bud pattern or the appearance of micronodules distributed at the termination of bronchovascular bundles, may be observed in certain forms of NTPE.Increased awareness of NTPE as an underestimated cause of acute and chronic embolism, which may result in acute and chronic pulmonary hypertension, is needed. Despite the fact that detailed descriptions of several forms of NTPE have existed for nearly 100 years, well-designed trials have never been performed to evaluate therapy in the different subsets of these patients.

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“…Embolismo aéreo: En estos tipos de muerte hay que tener precaución desde un principio, es decir, mucho antes de abordarlo o incidir en el cadá-ver, puesto que pueden realizarse algunas pruebas que ayudan a evidenciar su presencia, a pesar de que estas autopsias, en su mayoría, se puedan considerar con hallazgos negativos inicialmente [38][39][40][41].…”

Section: Muerte Secundaria a Embolismosunclassified

Muerte por establecer y muerte súbita

Villa

2017

Colomb. forense

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Resumen.Propósito: este artículo se elaboró para crear conciencia en el campo forense sobre la importancia de conceptualizar claramente las muertes por establecer, aportando diferentes artículos vigentes disponibles, tomando lo más relevante y llevándolo a un contexto real. Periodo que se abarcó, origen y tipos de publicaciones: se realizó una búsqueda en bases de datos y en literatura descrita en libros forenses con información relevante sobre las muertes por establecer, tomando en cuenta un periodo entre 1908 y la actualidad con temas referentes a la muerte sú-bita en el ámbito forense y en el ámbito clínico médico. Punto de vista: en medio de la investigación forense nos vemos enfrentados a las muertes por establecer, que muchas veces son el talón de Aquiles de los investigadores forenses; la concepción y el concepto de la muerte por establecer deben estar claros desde el inicio del abordaje de caso; e incluso desde la escena de los hechos se debe tener claridad acerca de cómo se debe abordar y así determinar las causas y la manera de muerte con base en un todo como contexto final. Conclusiones: la muerte por establecer es un tipo de muerte que debe ser abordado de lo general a lo particular con unas bases sólidas, partiendo de la concepción clara del forense que asume el caso, el abordaje con metodología y progresión en pasos ordenados descritos con detalle en el protocolo de autopsia, hasta la elaboración de una conclusión.Palabras clave: muerte súbita, forense, establecer, desconocido, no identificado.

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Immunologic Studies in Presumed Amniotic Fluid Embolism

Cited by 41 publications

References 18 publications

Amniotic fluid embolism in an HIV-positive parturient

Amniotic fluid embolism in an HIV-positive parturient

Nonthrombotic pulmonary embolism

Muerte por establecer y muerte súbita

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