Immunologic Response of Patients With Psoriasis

Landau, Joseph W.

doi:10.1001/archderm.1965.01600120039007

Cited by 20 publications

(9 citation statements)

References 11 publications

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“…Following vaccination with plague antigen, psoriatic patients receiving cytostatic drug therapy generally fail to develop antibodies. Depaoli [3] and Meneghini et al [6] reported similar results whereas other authors' [5,7] findings differ from them in certain points.…”

mentioning

confidence: 77%

Comparative Studies of Rubella Antibodies in Psoriatic Patients Treated with Methotrexate

Remy¹,

H²,

Antoniadis³

1974

Dermatology

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Rubella antibody titers were measured in psoriatic patients using the HAH test. Some patients received immuno-suppressive therapy while others did not. The difference between antibody titers in both groups was not significant. Antibody titers in patients with verified rubella did not change after a booster vaccination. These results are discussed in view of Epstein’s assumption of an immunologic block in psoriatic patients. At least, the comparative study of titers in psoriatic patients and healthy subjects does not suggest an impairment in rubella antibody synthesis.

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mentioning

confidence: 77%

Comparative Studies of Rubella Antibodies in Psoriatic Patients Treated with Methotrexate

Remy¹,

H²,

Antoniadis³

1974

Dermatology

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“…Semi-quantitative determination of the serum immunoglobulins in psoriasis has given more or less conflicting results in the past (Krebs et al, 1963;Laugier and Zimmer, 1963;Laugier et al, 1964;Landau et al, 1965;Petres et al, 1967). Fraser et al (1969, using a simple quantitative gel diffusion technique devised by Fahey and McKelvey (1965), found an increase of the IgA globulin and a decrease of the IgM globulin levels.…”

Section: Discussionmentioning

confidence: 99%

Serum Immunoglobulins in Psoriasis Before and After Ultra Violet Light Therapy

Varelzidis

Theodoridis

2006

British Journal of Dermatology

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SUMMARY.— A significant increase of the mean IgA globulin value was noted in 105 patients with ordinary psoriasis whereas the mean IgG and IgM globulin levels remained normal. Thirty‐two of these patients received u.v. light therapy which resulted in resolution of the skin lesions. At this stage the IgA levels fell to the normal range. The possibility of the skin eruption influencing the IgA serum levels is discussed.

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“…Immunological studies on psoriatic patients identified changes in humoral immune reactions as part of the overall problem but not the cause (Aswaq et al, 1960;Harber et al, 1962). Efficacy of the cytotoxic drugs in the late 1960s paved the road for ideas about the role of the immune system in psoriasis (Harris, 1971;Landau et al, 1965). Further investigations in the 1970s revealed the role of immunologic factors in psoriasis.…”

Section: Pre-biologic Immunological History Of Psoriasismentioning

confidence: 99%