Immunologic response in patients with polytrauma

Мухаметов, У. Ф.; Lyulin, Sergey V.; Borzunov, D.Yu.; Ilyasova, Tatiana; Gareev, Ilgiz; Sufianov, Albert

doi:10.1016/j.ncrna.2022.09.007

Cited by 6 publications

(6 citation statements)

References 30 publications

(37 reference statements)

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“…Despite improvements in prognosis and survival, there is a lack of validated diagnostic tools for posttraumatic complications. In a retrospective study involving 188 patients after severely injured trauma the immunoregulatory index, in the polytrauma patients with purulent-inflammatory complications, was lower than in the patients without purulentinflammatory complications due to the reduced values of Th [7]. In our study the levels of Tregn in 1 st and 5 th day and Th17n, T127hin in 5 th day after injury differed significantly in groups without and with IC: patients from the latter group had it considerably lower.…”

Section: Figure 1 Dynamics Of Th Absolute Cell Count In the Critical ...contrasting

confidence: 47%

“…The similar data have been obtained in other studies. It has been shown that persistence of lymphopenia shaped by the decreasing level of Th in severe injury following trauma is correlated with severity and is associated with poorer prognosis [7].…”

Section: Resultsmentioning

confidence: 99%

“…T lymphocytes (Th) in severe injury [7]. Activity, absolute cell number and frequency of such T helper subpopulations as regulatory T lymphocytes (Treg) -CD4 + CD127 low CD25 high and Th17 lymphocytes (Th17) can be a significant marker in determining the severity of the pathological process and predicting its outcome.…”

Section: субпопуляции Th при травме у детейmentioning

confidence: 99%

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Dynamics of T helper subpopulations in the critical period of severe injury in children

Zakirov,

Petrichuk,

Freidlyn

et al. 2023

Med. immunol.

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Severe mechanical injury is one of the main reasons behind children’s disability and mortality. Severe injury induces a complex host immune response to tissue injury, a parallel pro- and anti-inflammatory state, bearing an elevated risk for infectious complications (IC) and/or multiple organ failure (MOF). This study aimed to determine the informative immunological criteria of traumatic injury severity and prognosis outcome in children (severe injury group (SInj, ISS ≥ 16), n = 87; mild/moderate injury group (MInj, ISS < 16), n = 34) based on the assessment of absolute cell count (abs) and percentage of such T helper subpopulations as regulatory T lymphocytes – CD4+CD127lowCD25high(Treg), Th17 lymphocytes – CD4+CD161+ and CD4+CD127higtCD25high T cells(T127hi) in severe injury cases grouped by the outcome (favorable, n = 47; unfavorable, n = 40) and depending on IC (n = 16) and the development of MOF (n = 11) on the 1st, 3d , 5th, 7th, 14th day after injury. The control group was comprised of 80 apparently healthy children comparable in age and sex. An inverse relationship between severity of injury, degree of blood loss and outcome of injury was revealed with the abs of all Th populations, but for Th abs and Treg abs the most significant correlation was found (Spearman’s R ≤ -0,70, p < 0.00001). For SInj group, a pronounced decrease of Th abs, Treg abs, T127hi abs and Th17 abs, in the acute post-traumatic period with an increase to 14 days was revealed. The values of in the first day for indicators of patients with MInj group correspond to the values of control group and significantly differ from SInj group. There are different kinetics of percentage Th subpopulations in peripheral blood of children with severe injuries. The Th17%CD4+ and T127hi%CD4+ significant increase in 1st-3d and 3d -7th days after injury respectively in comparation with сontrol and MInj groups. There were no differences between groups in terms of Treg%CD4+. The lower-level Treg abs in trauma patients admitted to the ICU is significantly associated with develop the infectious complications and outcome of trauma. The Th17 abs is significantly reduced in 3-7th days after the injury in the SInj group with MOF. The results of the study indicate that in children levels of Treg, T127hi and Th17 is significantly associated with severity of injury and may be used to predict outcome of trauma and assess the risk of IC and MOF.

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Section: Figure 1 Dynamics Of Th Absolute Cell Count In the Critical ...contrasting

confidence: 47%

Section: Resultsmentioning

confidence: 99%

Section: субпопуляции Th при травме у детейmentioning

confidence: 99%

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Dynamics of T helper subpopulations in the critical period of severe injury in children

Zakirov,

Petrichuk,

Freidlyn

et al. 2023

Med. immunol.

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“…It has been suggested that the burden of trauma could potentially lead to the failure of the individual's immune system, which can be identi ed using the correlation of the concentration/proportion of the level of cytokines presented by the patient 23 . Particularly, the failure of the immune system can favor the progression of sepsis or even death, in case of infection or contamination 25 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, IL-10 is a classic anti-in ammatory cytokine, which has been associated with a better prognosis in trauma victims, as it helps to modulate the in ammatory response, reducing excessive in ammation and protecting the body's tissues from additional damage [13][14][15] . Thus, while IL-6 levels can act as a marker of the intensity of the in ammatory response, IL-10 levels can serve as a marker of how the body is dealing with this in ammation [18][19][20] .…”

mentioning

confidence: 99%

Relationship between IL-6 and IL-10 Inflammatory Cytokines and Severity Criteria in Trauma Victims.

de Oliveira,

Shio,

Bachi

et al. 2023

Preprint

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Background: The severity of the clinical status of polytrauma patients may be associated with an increase in the systemic inflammatory state mediated by cytokines. In fact, it has been suggested that the levels of pro- and anti-inflammatory cytokines can be used as prognostic indicators in trauma patients, since higher levels of IL-6 and lower levels of IL-10 are associated with worse outcomes, according to the trend shown in recent studies. Therefore, the objective of this study was to verify the relationship between the levels of these cytokines and the severity of the trauma. Methods: Prospective and analytical study carried out with 20 patients over 18 years of age, victims of trauma, who met the criteria for transfusion of blood components according to the Shock Index (SI) and Assessment of Blood Consumption (ABC Score) as a predictor of severity, at the time of admission (T0) and 48 hours after (T1) admission to the emergency room. Blood samples were collected at these two times to assess the serum concentration of IL-6 and IL-10. Results: Most patients were male (90%), with a mean age of 33.2 years. In total, 18 patients scored on the Shock Index (90%), 2 patients scored on the ABC Score (10%), and 6 patients (30%) received a score on both. Lower serum IL-10 concentrations were observed at T1 than at T0. IL-6 levels showed no differences between times. Significant positive correlations between IL-6 and IL-10 were evidenced at T0 (p=0.0065) and T1 (p=0.0263). There was an association of IL-6 levels with the ABC score and of IL-10 with the SI score. Conclusion: Although IL-6 serum levels alone did not change, IL-10 levels were reduced 48 hours after patient admission. In addition, the criteria for patient selection showed a significant association with the cytokines IL-6 and IL-10, suggesting that in addition to being predictors of blood transfusion, they could also be used as markers of severity in polytrauma patients.

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Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma

Zhang,

Fu,

Han

et al. 2024

Anim Models and Exp Med

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BackgroudThoracic Trauma and Limb Fractures Are the Two most Common Injuries in Multiple Trauma. However, there Is Still a Lack of Mouse Models of Trauma Combining Tibial Shaft Fracture (TSF) and Thoracic Trauma. In this Study, we Attempted to Develop a Novel Mouse Model of TSF Combined with Blunt Chest Trauma (BCT).MethodsA total of 84 C57BL/6J male mice were used as the multiple trauma model. BCT was induced by hitting the chests of mice with heavy objects, and TSF was induced by hitting the tibia of mice with heavy objects after intramedullary fixation. Serum specimens of mice were received by cardiac puncture at defined time points of 0, 6, 12, 24, 48, and 72 h.ResultsBody weight and body temperature tended to decrease within 24 h after multiple trauma. Hemoglobin analyses revealed a decrease during the first 24 h after multiple trauma. Some animals died by cardiac puncture immediately after chest trauma. These animals exhibited the most severe pulmonary contusion and hemorrhage. The level of lung damage varied in diverse mice but was apparent in all animals. Classic hematoxylin and eosin (H&E)‐stained paraffin pulmonary sections of mice with multiple trauma displayed hemorrhage and an immunoinflammatory reaction. Bronchoalveolar lavage fluid (BALF) and serum samples of mice with multiple trauma showed an upregulation of interleukin‐1β (IL‐1β), IL‐6, and tumor necrosis factor‐1α (TNF‐1α) compared with the control group. Microimaging confirmed the presence of a tibia fracture and pulmonary contusion.ConclusionsThe novel mouse multiple trauma model established in this study is a common trauma model that shows similar pathological mechanisms and imaging characteristics in patients with multiple injuries. This study is useful for determining whether blockade or intervention of the cytokine response is beneficial for the treatment of patients with multiple trauma. Further research is needed in the future.

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Immunologic response in patients with polytrauma

Cited by 6 publications

References 30 publications

Dynamics of T helper subpopulations in the critical period of severe injury in children

Dynamics of T helper subpopulations in the critical period of severe injury in children

Relationship between IL-6 and IL-10 Inflammatory Cytokines and Severity Criteria in Trauma Victims.

Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma

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