Immunologic rejection of human cancer transplanted with a renal allograft

Wilson, R E; Hager, Edward B.; Hampers, Constantine L.; Corson, Joseph M.; Merrill, John P.; Murray, J E

doi:10.1097/00007890-196808000-00030

Cited by 15 publications

(18 citation statements)

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“…These cases have included donor transmitted neuroendocrine carcinoma (13), Kaposi's sarcoma (17), leiomyosarcoma (16), melanoma (11), adenocarcinomas (18,26), glioblastomas (15,27,28), and choriocarcinomas (12,14,24,25) Our case represents such a case and, to our knowledge, is the only reported case of donor-transmitted SCC occurring in a transplanted liver. Epidermoid cancers have been reported to be transmitted to renal recipients (29). Four cases of donor transmitted liver malignancies treated with retransplantation have been reported (18,26,30).…”

Section: Discussionmentioning

confidence: 99%

“…Under these conditions, the transplanted organ harboring an occult metastasis or primary focus of carcinoma provides a fertile environment for tumor growth and dissemination (11,35). As a result, cessation of immunosuppression makes at least theoretical sense and, in certain cases, has been shown to be effective in the treatment of donor-transmitted malignancies (8,29). Just as a transplanted organ is rejected without immunosuppression, a transplanted malignancy may be similarly rejected.…”

Section: Discussionmentioning

confidence: 99%

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Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Florman¹,

Bowne²,

Kim‐Schluger³

et al. 2004

American Journal of Transplantation

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Posttransplantation allograft malignancy of donor origin is a rare complication after liver transplantation. In the case described, subjective fevers and nonspecific abdominal complaints nearly 6 months following cadaveric liver transplantation in a young woman prompted an evaluation which was remarkable for a large central liver mass. A poorly differentiated squamous cell carcinoma was diagnosed, but was unresectable at exploration. The tumor was confined to the liver. Histocompatibility testing using polymerase chain reaction (PCR) amplification techniques identified both donor and recipient HLA alleles. The patient was treated with chemoembolization, systemic chemotherapy and cessation of immunosuppression. Repeat biopsy 2 months later showed the tumor to be completely necrotic. With decompensated liver disease, she was relisted and retransplanted. More than 2 years later she remains disease-free with complete pathological remission. This is the only reported case of squamous cell carcinoma of donor origin arising in a transplantd liver.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Florman¹,

Bowne²,

Kim‐Schluger³

et al. 2004

American Journal of Transplantation

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“…Reports of melanoma transmission resulting in disseminated disease in organ transplant recipients have been published (3). Other cancers known to be transmitted from donor to recipient include tumors of neuroendocrine origin, prostate carcinoma, choriocarcinoma, advanced renal carcinoma and lung cancer (4). Sarcoma, often highly malignant, is an uncommon cancer, and we found no other organ donor with sarcoma reported in the literature.…”

Section: Introductionmentioning

confidence: 68%

Extended Survival by Urgent Liver Retransplantation after Using a First Graft with Metastasis from Initially Unrecognized Donor Sarcoma

Ortíz¹,

Manzarbeitia²,

Noto³

et al. 2005

American Journal of Transplantation

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A 58-year-old man underwent orthotopic liver transplantation for polycystic liver disease. Shortly after the procedure, it was discovered that the donor harbored a sarcoma of the aortic arch that had metastasized to the spleen, and bilateral renal cell carcinomas. The two sole organ recipients, our liver recipient and a lung recipient at another institution, were both listed for urgent retransplantation, which they received from the same second donor. The liver explant contained metastatic sarcoma. Twenty-four months survival following lung retransplantation has been previously reported. We report the 76-month disease-free survival in the liver recipient.

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“…Although there have been instances in which cessation of immunosuppression has contributed to the cure of a donor-derived neoplasm, including broncho- genic carcinoma transferred by kidney transplantation, 3 progression of malignancy despite restitution of the immune system also has been well documented. 4,5 Therefore, in today's climate of critical organ shortage, for a potential donor with known malignancy, either past or current, the estimated risk for cancer transmission tempers the evaluation, consideration, and acceptance of his or her organs by the individual transplant physicians and candidates.…”

Section: Discussionmentioning

confidence: 99%

Death from donor-transmitted malignancy despite emergency liver retransplantation

Lipshutz

Baxter‐Lowe

Nguyen

et al. 2003

Liver Transplantation

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Transplantation of organs procured from donors with malignancies identified subsequent to implantation presents a significant dilemma regarding the optimal management strategy to simultaneously minimize the risk for cancer transmission and recipient morbidity. In this report, we present a patient who underwent orthotopic liver transplantation for hepatitis B cirrhosis. The donor had no previous history of cancer. On autopsy, enlarged mediastinal lymph nodes led to the discovery of a 1-cm lung tumor. Histological examination showed pulmonary adenocarcinoma with metastatic mediastinal disease. Despite urgent retransplantation within 7 days, the recipient developed metastatic pulmonary adenocarcinoma diagnosed 11 months after transplantation and died soon thereafter. Analysis of short tandem repeat regions of chromosomal DNA from the recipient, the 2 liver donors, and the posttransplantation tumor corroborates that the first donor was the source of the malignancy. This case of donor-transmitted malignancy underscores the need for vigilance by the procuring surgeon in identifying potential malignancy during organ retrieval and use of a full autopsy on selected donors after organ procurement. (Liver Transpl 2003;9:1102-1107.)

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Immunologic rejection of human cancer transplanted with a renal allograft

Cited by 15 publications

References 0 publications

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Extended Survival by Urgent Liver Retransplantation after Using a First Graft with Metastasis from Initially Unrecognized Donor Sarcoma

Death from donor-transmitted malignancy despite emergency liver retransplantation

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