Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells

Zhang, Yujing; Shen, Li; Zhang, Tao; Muyayalo, Kahindo P; Luo, Jing; Mor, Gil; Liao, Aihua

doi:10.7150/ijbs.70629

Cited by 5 publications

(3 citation statements)

References 99 publications

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“…To date little is known about Treg cells in the reproductive tract. Most studies have focused on pregnancy as Treg cells play a crucial role for pregnancy success, providing immunological tolerance to the fetus (144). To support this, Treg cells expand in the endometrium and decidua induced by elevated human chorionic gonadotropin (hCG) levels after fertilization (145), peak during the second trimester, and finally decrease towards birth (146).…”

Section: Tissue Treg Cells In Reproductive Organsmentioning

confidence: 99%

Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology

2022

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Treg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during infections and tumor development. Furthermore, Treg cells can acquire additional properties for e.g., the control of tissue homeostasis. This is instructed by a specific differentiation program and the acquisition of effector properties unique to Treg cells in non-lymphoid tissues. These tissue Treg cells can further adapt to their tissue environment and acquire distinct functional properties through specific transcription factors activated by a combination of tissue derived factors, including tissue-specific antigens and cytokines. In this review, we will focus on recent findings extending our current understanding of the role and differentiation of these tissue Treg cells. As such we will highlight the importance of tissue Treg cells for tissue maintenance, regeneration, and repair in adipose tissue, muscle, CNS, liver, kidney, reproductive organs, and the lung.

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Section: Tissue Treg Cells In Reproductive Organsmentioning

confidence: 99%

Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology

2022

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“…Healthy pregnancy requires the maternal immune system to tolerate the fetus with a different major histocompatibility complex (MHC) [15][16][17]. This occurs when the activated maternal immune effectors are triggered by the trophoblast antigens to regulate the adaptive immune system [18].…”

Section: Introductionmentioning

confidence: 99%

“…This occurs when the activated maternal immune effectors are triggered by the trophoblast antigens to regulate the adaptive immune system [18]. Effectors in this immune balance include T-helper (Th), T-cytotoxic, T-Tregs, and B-cells [15,16]. T-cell differentiation to specific subtypes is critical to the desired function to maintain immune balance during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Restore Veto Property in Low Dose Aspirin/ASA Treated Preeclampsia Placenta Mesenchymal Stem Cells: Insights Into ASA-mediated Clinical Response*

Powell,

Sherman,

Shadpoor

et al. 2024

IJTS

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Preeclampsia (PE) is a pregnancy complication characterized by elevated blood pressure, proteinuria, and other laboratory abnormalities. PE affects 2–8% of pregnancies globally and can lead to preterm birth and other complications for the mother and fetus. Successful pregnancy depends on the ability of the mother’s immune system to tolerate the allogeneic fetus. However, in PE, this immune tolerance is exacerbated by inflammation. Transforming growth factor β (TGF-β) is important to retain an immune balance in healthy pregnancy. In PE, TGF-β level is reduced, with an imbalance of the T-cell subset pool to favor inflammation. Omics studies by our group reported an increase in TGF-β signaling when PE-derived placenta mesenchymal stem cells (P-MSCs) were treated with low dose aspirin (ASA). This correlated with increased cycling quiescence and epigenetic changes, resembling healthy P-MSCs. This study tested the hypothesis that ASA could restore the veto property of P-MSCs to mitigate inflammation. ASA (10 mM) treated P-MSCs from PE and healthy placentas increased TGFβ1 and its receptor. The ASA treated MSCs, when added as third-party cells to a one-way mixed lymphocyte reaction, suppressed T-cell proliferation. Prediction studies with omics data indicated that ASA-mediated TGFβ signaling could explain ASA-induced blunting of cell apoptosis. Together, the findings support ASA-mediated expression of TGFβ1 and its receptor on P-MSCs from PE to restore the ability to be licensed as immune suppressor to mitigate PE inflammation. The findings provide new insight into the benefit of ASA treatment for PE.

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Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia

Suvakov,

Kattah,

Gojkovic

et al. 2023

Comprehensive Physiology

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The incidence of hypertensive disorders of pregnancy is increasing, which may be due to several factors, including an increased age at pregnancy and more comorbid health conditions during reproductive years. Preeclampsia, the most severe hypertensive disorder of pregnancy, has been associated with an increased risk of future disease, including cardiovascular and kidney diseases. Cellular senescence, the process of cell cycle arrest in response to many physiologic and maladaptive stimuli, may play an important role in the pathogenesis of preeclampsia and provide a mechanistic link to future disease. In this article, we will discuss the pathophysiology of preeclampsia, the many mechanisms of cellular senescence, evidence for the involvement of senescence in the development of preeclampsia, as well as evidence that cellular senescence may link preeclampsia to the risk of future disease. Lastly, we will explore how a better understanding of the role of cellular senescence in preeclampsia may lead to therapeutic trials. © 2023 American Physiological Society. Compr Physiol 13:5077‐5114, 2023.

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Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells

Cited by 5 publications

References 99 publications

Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology

Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology

Restore Veto Property in Low Dose Aspirin/ASA Treated Preeclampsia Placenta Mesenchymal Stem Cells: Insights Into ASA-mediated Clinical Response*

Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia

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