Immunologic Inhibition of the Biological Effects of Relaxin

Cohen, H; Graff, Miriam

doi:10.1210/endo-72-1-164

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1963

2017

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Cited by 6 publications

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“…The results of the present study confirm and extend the finding of Cohen & Graff (1963) that relaxin has antigenic activity. The antibody to relaxin obtained from rabbits treated with porcine relaxin was active in all the immunological tests and in 25 (17) 1-58 + 0-100 1-0 (i.p.…”

Section: Discussionsupporting

confidence: 92%

“…However, refractory states observed in guinea-pigs after repeated bioassays of the hormone (Noall & Frieden, 1956;Frieden, 1958) and reports of localized transient chills or pain (Perkoff, Salhanick, Zarrow, Nelson & Tyler, 1954;Kelly & Posse, 1956;Eichner, Waltner, Goodman & Post, 1956) and anaphylactic reactions (Evans, 1959;Wendt & Wolfe, 1959) in the clinical literature indicated that an antibody to relaxin might be produced. The formation of a relaxin antibody in rabbits was first reported by Cohen (Cohen, 1963;Cohen & Graff, 1963). This study confirms the ability of relaxin to induce antibody formation in the rabbit and presents data on the biological and immunological characteristics of the antibody.…”

Section: Introductionsupporting

confidence: 85%

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