Immunologic Function in the Elderly After Injury—The Neutrophil and Innate Immunity

Abstract

Injury results in differences in innate immune function in the elderly when compared with controls. The clinical significance of this is uncertain and warrants further investigation.

Risk factors for sepsis in Korean trauma patients

“…Age is also strongly correlated with sepsis development in non-trauma patients, as well as in trauma patients [14]. As patients' age increases, differences appear in their health status, and consequently there are increased comorbidities, which contribute to the failure to establish effective and adequate defense mechanisms in the early stages of trauma [15].…”

Multiplexed measurements of immunomodulator levels in peripheral blood of healthy subjects: Effects of analytical variables based on anticoagulants, age and gender

“…These changes include reduction in response and modulation in regulatory and immune effector cells leading to changes in expression of various chemokines and cytokines (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). Shurin et al (37) investigated the effect of age on 30 different serum biomarkers involved in pro-and anti-inflammatory responses.…”

Survival outcomes after prolonged intensive care unit length of stay among trauma patients: The evidence for never giving up

“…Increasing age is also known to decrease physiologic reserves, altering the ability of injured older adult patients to mount and sustain a response to traumatic injury. 32,33 While limited in its inclusion to adults aged <65 years, these tendencies would be expected to hold true within our study population as well.…”