Immunologic events in pigeon breeders' disease

Moore, Vernon L.; Fink, Jordan N.; Barboriak, Joseph J.; Ruff, L; Schlueter, Donald P.

doi:10.1016/0091-6749(74)90115-8

Cited by 116 publications

(47 citation statements)

References 23 publications

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“…; Recently we observed that asymptomatic pigeon breeders displayed a serum complement (CH5o) depression subsequent to an aerosol challenge with pigeon serum, while symptomatic breeders did not exhibit such a serum complement depression after similar challenge (4). Interestingly, both groups have serum precipitating, complement-fixing antibodies to pigeon serum antigens (4,7). Furthermore, we observed that peripheral leukocytes from the symptomatic group produced migration inhibition factor (s) (MIF) in vitro when challenged with pigeon antigens; leukocytes from asymptomatic breeders did not produce these factors (4).…”

Section: Introductionmentioning

confidence: 99%

“…These findings suggest that other factor (s) are involved in the induction of the disease in addition to the inhalation of antigens with subsequent antibody synthesis. ; Recently we observed that asymptomatic pigeon breeders displayed a serum complement (CH5o) depression subsequent to an aerosol challenge with pigeon serum, while symptomatic breeders did not exhibit such a serum complement depression after similar challenge (4). Interestingly, both groups have serum precipitating, complement-fixing antibodies to pigeon serum antigens (4,7).…”

Section: Introductionmentioning

confidence: 99%

“…The present study in rabbits was therefore designed to: (a) study the induction of hypersensitivity pneumonitis by antigen inhalation in combination with an agent known to activate T cells and (b) test some of the events in the experimental animal model that we have observed in human studies (4). METHODS Antigeni.…”

Section: The Journal Of Clinical Investigationmentioning

confidence: 99%

“…Interestingly, both groups have serum precipitating, complement-fixing antibodies to pigeon serum antigens (4,7). Furthermore, we observed that peripheral leukocytes from the symptomatic group produced migration inhibition factor (s) (MIF) in vitro when challenged with pigeon antigens; leukocytes from asymptomatic breeders did not produce these factors (4). These findings have suggested that cellular immune mechanisms 'Abbreviationis used in this paper: CMH, cell-mediated hypersensitivity; H&E, hematoxylin and eosin; MIF, migration inhibition factor; PDE, pigeon dropping extract; T cell, thymus-derived lymphocyte.…”

Section: Introductionmentioning

confidence: 99%

“…Hypersensitivity pneumonitis is an allergic lung disorder characterized by fever, chills, and dyspnea in its acute phase (1), the presence of serum precipitating antibodies to the implicated antigens (2), and cell-mediated hypersensitivity (CMH)' in at least one of these disorders (3)(4)(5). These diseases are presumably due to the continued or intermittent inhalation of a wide variety of organic dusts (6), i.e., the route of antigen exposure that leads to a hypersensitivity state is through the respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An animal model of hypersensitivity pneumonitis in the rabbit.

Moore¹,

Hensley²,

Fink³

1975

J. Clin. Invest.

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A B ST R A CT This study was devised to produce an animal model of hypersensitivity pneumonitis in order to study both the induction and the elicitation of the disease. Rabbits exposed by aerosol to large quantities of pigeon antigens developed a humoral, but not cellular, immunologic response. Moreover, their lungs were essentially normal histologically. A single i.v. injection of killed BCG in oil permitted the induction of pulmonary cell-mediated hypersensitivity to the inhaled antigen, as well as the development of pulmonary lesions which were more severe than that caused by the administration of BCG alone. The humoral immunologic response to the inhaled antigen was not increased after BCG injection. Since many individuals are exposed to the etiologic agents of hypersensitivity pneumonitis for extended periods without developing the disease, these findings in animals suggest that some event may occur to induce cell-mediated hypersensitivity in order to initiate the disease process.In addition, we have shown that animals with normal lung histology and circulating complement-fixing antibodies undergo serum complement (CH50) depression after an aerosol challenge with the specific antigen. Animals with circulating, complement-fixing antibodies, and inflamed lungs (BCG-induced) failed to undergo a complement depression subsequent to an aerosol challenge with specific antigens. These results are consistent with those seen in symptomatic and asymptomatic pigeon breeders and suggest that antigen distribution through the lung is important in the pathogenesis of hypersensitivity pneumonitis.Preliminary reports of this research were presented at

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: The Journal Of Clinical Investigationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An animal model of hypersensitivity pneumonitis in the rabbit.

Moore¹,

Hensley²,

Fink³

1975

J. Clin. Invest.

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Allergic Alveolitis Caused by Home Humidifiers

Burke¹

1977

JAMA

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Allergic alveolitis (hypersensitivity pneumonitis) developed in two patients who were exposed to home humidifiers contaminated by thermophilic actinomycetes. Diagnosis was difficult because severe dyspnea was chronic and not easily associated with specific environmental exposure. Furthermore, chest roentgenograms were normal for long periods despite severe physiologic abnormalities. After several years of disabling symptoms, open lung biopsy findings suggested allergic alveolitis rather than sarcoidosis because a mononuclear interstitial infiltrate overshadowed the granulomas. Also, plasma cells were prominent and there was an intense bronchiolitis. Cultures of the humidifier water grew thermophilic organisms to which the patient's sera formed precipitins. Both patients experienced notable subjective and objective improvement following removal of the contaminated appliances. The ultrastructure of alveolar macrophages and basement membranes was similar to that described in animal models, suggesting cell-mediated hypersensitivity in the patients.

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Sauna-takers disease. Hypersensitivity pneumonitis due to contaminated water in a home sauna

Metzger¹

1976

JAMA: The Journal of the American Medical Association

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Daily saunas taken by a young man were followed by fever, chills, malaise, dyspnea, cough, and myalgia from six to eight hours later. Symptoms, which were related to pouring water from a sauna bucket over the heating element, progressed to chronic dyspnea and fatigue. Serial serum samples showed precipitin reactions to bucket water and extracts of bucket mold. IgG antibody activity, demonstrated by radioimmunoassay, suggested that Pullularia was a major antigen.

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Immunologic events in pigeon breeders' disease

Cited by 116 publications

References 23 publications

An animal model of hypersensitivity pneumonitis in the rabbit.

An animal model of hypersensitivity pneumonitis in the rabbit.

Allergic Alveolitis Caused by Home Humidifiers

Sauna-takers disease. Hypersensitivity pneumonitis due to contaminated water in a home sauna

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