Immunologic Dialogue between Cardiac Myocytes, Endothelial Cells, and Mononuclear Cells

Ansari, Aftab A.; Neckelmann, Nicolas; Wang, Y.C.; Gravanis, Michael B.; Sell, Kenneth W.; Herskowitz, Ahvie

doi:10.1006/clin.1993.1120

Cited by 49 publications

(23 citation statements)

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“…19 This interesting association between PPCM and twin pregnancies may support an autoimmune mechanism for PPCM. Such a mechanism has recently been proposed by Ansari et al, 20 who found high titers of autoantibodies against normal human cardiac tissue proteins in the sera of PPCM patients that were not present in patients with idiopathic cardiomyopathy. This finding may be due to hematopoietic lineage cell traffic (chimerism) from the fetus to the mother during gestation, which is increased in twin pregnancies.…”

Section: Discussion Clinical Profile Of Ppcmmentioning

confidence: 74%

Pregnancy-Associated Cardiomyopathy

et al. 2005

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Background-Cardiomyopathy associated with pregnancy was first described more than half a century ago. However, because of its rare occurrence and geographical differences, the clinical profile of this condition has remained incompletely defined. Methods and Results-Data obtained from 123 women with a history of cardiomyopathy diagnosed during pregnancy or the postpartum period were reviewed. One hundred women met traditional criteria of peripartum cardiomyopathy; 23 were diagnosed with pregnancy-associated cardiomyopathy earlier than the last gestational month. Peripartum cardiomyopathy patients had a mean age of 31Ϯ6 years and were mostly white (67%). Common associated conditions were gestational hypertension (43%), tocolytic therapy (19%), and twin pregnancy (13%). Left ventricular ejection fraction at the time of diagnosis was 29Ϯ11% and improved to 46Ϯ14% (PՅ0.0001) at follow-up. Normalization of left ventricular ejection fraction occurred in 54% and was more likely in patients with left ventricular ejection fraction Ͼ30% at diagnosis. Maternal mortality was 9%. A comparison between the peripartum cardiomyopathy and early pregnancy-associated cardiomyopathy groups revealed no differences in age, race, associated conditions, left ventricular ejection fraction at diagnosis, its rate and time of recovery, and maternal outcome.

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Section: Discussion Clinical Profile Of Ppcmmentioning

confidence: 74%

Pregnancy-Associated Cardiomyopathy

et al. 2005

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“…In a study of Ansari AA, the immunological role of development of PPCMP has also been reported. 18 Mason JW, et al and Bozkurt B, et al have also supported immunological basis of development of PPCMP as their patients improved following immunosuppressive therapy. [19][20][21][22] Gestational hypertension found in 5 patients (16%) of this series is in contrast to 43% figure as reported by Elka Yamu, et al 15 Three patients (10% ) in our study had toxaemia of pregnancy which is also in contrast to O'Connell JB, et al who have reported 27% of their patients with toxaemia of pregnancy 21 , however, study by Masood, et al have reported 16.6% of their patients with toxaemia.…”

Section: Discussionmentioning

confidence: 87%

Risk Factors Associated With Peripartum Cardiomyopathy

2005

J Liaquat Uni Med Health Sci

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“…[12][13][14][15] However, the cause of myocardial damage is unknown. 6) There were no cases of PPCM in our study population.…”

Section: Discussionmentioning

confidence: 99%

Detection of Peripartum Myocardial Burden by Vector-Projected 187 Channel Electrocardiography and Serum NT-proBNP

et al. 2013

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SummaryThere is no reliable method of screening for pregnant women at high risk of developing severe myocardial disorders. In this study, we used vector-projected 187 channel electrocardiography (DREAM-ECG) and serum biochemical markers to evaluate peripartum myocardial burden in pregnant women. Forty-one pregnant women were examined at 36-37 weeks gestation (GW36), 7 days postpartum (PPD7), and 1 month postpartum (PPM1). Ten non-pregnant control women were assessed at a single time point. Heart rate, sympathetic index, and repolarization index (RTc dispersion) were quantified using the DREAM-ECG system, and serum levels of NT-proBNP, cardiac troponin T, estrogen, and progesterone were determined. Heart rate and the sympathetic index decreased from GW36 to PPM1 (P = 0.0031). The repolarization index decreased over time and was greater than in non-pregnant controls (31 ± 13 ms). Estrogen and progesterone at PPD7 and PPM1 were significantly lower than those at GW36 (P < 0.0001, P < 0.001). NT-proBNP at PPD7 was greater than at GW36 (median 29 pg/mL at GW36, 86 pg/mL at PPD7), and decreased at PPM1 in comparison to PPD7 (median 18.5 pg/mL). Troponin T was in the normal range during the whole period (< 0.003 ng/mL). In conclusion, these results indicate that the peripartum myocardial burden in pregnant women does not return to normal nonpregnant levels by PPM1. We propose that both repolarization indexes such as RTc dispersion by DREAM-ECG and serum biochemical markers may identify pregnant women at high risk of developing severe myocardial damage in the peripartum period. (Int Heart J 2013; 54: 140-145)

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Immunologic Dialogue between Cardiac Myocytes, Endothelial Cells, and Mononuclear Cells

Cited by 49 publications

References 0 publications

Pregnancy-Associated Cardiomyopathy

Pregnancy-Associated Cardiomyopathy

Risk Factors Associated With Peripartum Cardiomyopathy

Detection of Peripartum Myocardial Burden by Vector-Projected 187 Channel Electrocardiography and Serum NT-proBNP

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