Immunologic Defects and Vaccination in Patients With Chronic Renal Failure

Pesanti, Edward L.

doi:10.1016/s0891-5520(05)70174-4

Cited by 122 publications

(75 citation statements)

References 110 publications

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“…5 There is greater susceptibility to infections, hyporesponsiveness to vaccination and impairment of cellular and humoral immunities. 5 Although IFAT does not discriminate between past and current infections and presents cross-reactions with others diseases, such as malaria, cutaneous leishmaniasis and Chagas disease, these influences could be attenuated because none of the subjects had a past history of them, the first two diseases are not present in the study region and the ELISA for Chagas disease was reactive in only one patient.…”

Section: Discussionmentioning

confidence: 99%

Presence of antibodies against Leishmania chagasi in haemodialysed patients

Souza

Oliveira

Paiva

et al. 2009

Transactions of the Royal Society of Tropical Medicine and Hygi

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a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r h e a l t h . c o m / j o u r n a l s / t r s t SHORT COMMUNICATION Presence of antibodies against SummaryIn the last decades there has been an increase in cases of visceral leishmaniasis complicating the post-transplant phase, mainly following kidney transplantation. The aim of this study was to evaluate the reactivity of haemodialysed patients using IFAT. Blood samples of 310 individuals from Natal, RN, Brazil, were collected and analysed. Data regarding blood transfusion, cause of end-stage renal disease and duration of haemodialysis were also analysed. In total, 69 patients (22.3%) were positive by IFAT. This study suggests that antibody detection should be performed in this group of patients since they are possible candidates for kidney transplantation.

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Section: Discussionmentioning

confidence: 99%

Presence of antibodies against Leishmania chagasi in haemodialysed patients

Souza

Oliveira

Paiva

et al. 2009

Transactions of the Royal Society of Tropical Medicine and Hygi

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“…Alterations in the host immune response have primarily been studied in the ESRD population. In these patients, the function of polymorphonuclear white blood cells, lymphocytes, and monocytes is altered, resulting in an impaired host response to infection (25)(26)(27). Malnutrition, increased intracellular calcium, iron overload, dialysis membranes, and uremic toxins (i.e., circulating factors that inhibit granulocytes) contribute to impaired polymorphonuclear leukocyte function (18,26).…”

Section: Risk Factors For Infection In Ckd and Esrdmentioning

confidence: 99%

“…Patients with ESRD have a reduced response to vaccinations, which is ascribed to alterations in the immune system (27). In general, patients with kidney dysfunction have been observed to have lower rates of vaccine response and a more rapid decline of antibody levels after vaccination (30).…”

Section: Risk Factors For Infection In Ckd and Esrdmentioning

confidence: 99%

Epidemiology of Acute Infections among Patients with Chronic Kidney Disease

Dalrymple¹,

Go²

2008

Clinical Journal of the American Society of Nephrology

197

183

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The objectives of this review were (1) to review recent literature on the rates, risk factors, and outcomes of infections in patients who had chronic kidney disease (CKD) and did or did not require renal replacement therapy; (2) to review literature on the efficacy and use of selected vaccines for patients with CKD; and (3) to outline a research framework for examining key issues regarding infections in patients with CKD. Infection-related hospitalizations contribute substantially to excess morbidity and mortality in patients with ESRD, and infection is the second leading cause of death in this population. Patients who have CKD and do not require renal replacement therapy seem to be at higher risk for infection compared with patients without CKD; however, data about patients who have CKD and do not require dialysis therapy are very limited. Numerous factors potentially predispose patients with CKD to infection: advanced age, presence of coexisting illnesses, vaccine hyporesponsiveness, immunosuppressive therapy, uremia, dialysis access, and the dialysis procedure. Targeted vaccination seems to have variable efficacy in the setting of CKD and is generally underused in this population. In conclusion, infection is a primary issue when caring for patients who receive maintenance dialysis. Very limited data exist about the rates, risk factors, and outcomes of infection in patients who have CKD and do not require dialysis. Future research is needed to delineate accurately the epidemiology of infections in these populations and to develop effective preventive strategies across the spectrum of CKD severity.

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“…The impaired immunogenicity in renal disease patients has been explained by different mechanisms, most notably impaired cellular immunity system in this population [28][29][30] . However, clinical trials have also proposed several other factors having predictive values in this era; but due to the controversial evidence provided by different reports, systematic reviews and metaanalyses have been conducted to pool data of all the published trials to provide a thorough conclusion from the cumulative data.…”

Section: Discussionmentioning

confidence: 99%

Sex bias in response to hepatitis B vaccination in end-stage renal disease patients: Meta-analysis

Khedmat

Aghaei

Ghamar-Chehreh

et al. 2016

WJN

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AIM:To systematically review the literature for studies investigating the potential effect of gender of dialysis patients on the immunogenicity of hepatitis B virus vaccines. METHODS:Literature searches were conducted by the MEDLINE and Google Scholar. The key words used included "hepatitis B (HB)", "vaccine", "dialysis", "hemodialysis", "sex", "male" and "female". Data of seroresponse to HB vaccine in clinical trials regarding sex of the recipients have been achieved and analyzed. Finally data from 19 clinical trials have been pooled and analyzed. RESULTS:Analysis of response to HB vaccination in our dialysis population showed males significantly respond less to hepatitis B vaccination (P = 0.002, Z = 3.08) with no significant heterogeneity detected [P = 0.766; heterogeneity χ 2 = 14.30 (df = 19); I 2 = 0%]. A reanalysis of the pooled data was conducted regarding the dialysis mode to evaluate potential differential impact of sex on HB vaccine response. Hemodialysis was the only subgroup that showed a significant difference regarding dialysis mode in response to HB vaccination regarding sex (P = 0.042, Z = 2.03). CONCLUSION:This Meta-analysis showed significant effect for the sex of chronic kidney disease and dialysis patients on the immunogenicity of HB vaccine. This sex discrimination was most prominent among hemodialysis patients.

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Immunologic Defects and Vaccination in Patients With Chronic Renal Failure

Cited by 122 publications

References 110 publications

Presence of antibodies against Leishmania chagasi in haemodialysed patients

Presence of antibodies against Leishmania chagasi in haemodialysed patients

Epidemiology of Acute Infections among Patients with Chronic Kidney Disease

Sex bias in response to hepatitis B vaccination in end-stage renal disease patients: Meta-analysis

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