Immunologic Contributions Following Rotator Cuff Injury and Development of Cuff Tear Arthropathy

Nelson, Grant; McMellen, Christopher J; Kolaczko, Jensen G.; Millett, Peter J.; Gillespie, Robert J.; Su, Charles A.

doi:10.2106/jbjs.rvw.21.00126

Cited by 3 publications

(2 citation statements)

References 60 publications

(106 reference statements)

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“…These 2 miRNAs have been found to be dysregulated in inflammation-related diseases, implying that they may involve in the inflammatory response in RCT (Duecker et al, 2022;Ling et al, 2022). Studies showed that inflammation in RCT contributes to fatty infiltration (Nelson et al, 2021), which is associated with poor surgical outcomes and postoperative failure of rotator cuff repair (Shen et al, 2008;Wieser et al, 2019), but the roles of hsa_circ_0000722 and their ceRNA interactions (hsa_circ_0000722-hsa-miR-129-5p-GPD2/ hsa_circ_0000722-hsa-miR-30c-5p-NCOA3) in rotator cuff tears remain to be elucidated. However, this study is based on a small sample of five pairs of torn supraspinatus muscle samples and matched unharmed subscapularis muscle samples, which may have limited generalizability.…”

Section: Discussionmentioning

confidence: 99%

Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears

Zhang

Xiao

et al. 2022

Front. Mol. Biosci.

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Background: Rotator cuff tears (RCT) is the most common cause of shoulder dysfunction, however, its molecular mechanisms remain unclear. Non-coding RNAs(ncRNAs), such as long ncRNA (lncRNA), microRNA (miRNA) and circular RNA (circRNA), are involved in a variety of diseases, but little is known about their roles in RCT. Therefore, the purpose of this study is to identify dysregulated ncRNAs and understand how they influence RCT.Methods: We performed RNA sequencing and miRNA sequencing on five pairs of torn supraspinatus muscles and matched unharmed subscapularis muscles to identify RNAs dysregulated in RCT patients. To better comprehend the fundamental biological processes, we carried out enrichment analysis of these dysregulated mRNAs or the co-expressed genes of dysregulated ncRNAs. According to the competing endogenous RNA (ceRNA) theory, we finally established ceRNA networks to explore the relationship among dysregulated RNAs in RCT.Results: A total of 151 mRNAs, 38 miRNAs, 20 lncRNAs and 90 circRNAs were differentially expressed between torn supraspinatus muscles and matched unharmed subscapularis muscles, respectively. We found that these dysregulated mRNAs, the target mRNAs of these dysregulated miRNAs or the co-expressed mRNAs of these dysregulated ncRNAs were enriched in muscle structure development, actin-mediated cell contraction and actin binding. Then we constructed and analyzed the ceRNA network and found that the largest module in the ceRNA network was associated with vasculature development. Based on the topological properties of the largest module, we identified several important ncRNAs including hsa_circ_0000722, hsa-miR-129-5p and hsa-miR-30c-5p, whose interacting mRNAs related to muscle diseases, fat and inflammation.Conclusion: This study presented a systematic dissection of the expression profile of mRNAs and ncRNAs in RCT patients and revealed some important ncRNAs which may contribute to the development of RCT. Such results could provide new insights for further research on RCT.

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Section: Discussionmentioning

confidence: 99%

Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears

Zhang

Xiao

et al. 2022

Front. Mol. Biosci.

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“…Studies evaluating PRP for the treatment of rotator cuff tendinopathy and tears is similarly mixed 28 . When evaluating PRP for augmentation of rotator cuff repairs, a meta-analysis of 18 Level-I studies found that long-term retear rates were significantly decreased in patients who received PRP 29 .…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

Current State of Platelet-Rich Plasma and Cell-Based Therapies for the Treatment of Osteoarthritis and Tendon and Ligament Injuries

Jildeh

Vopat

et al. 2022

Journal of Bone and Joint Surgery

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Orthobiologics encompass numerous substances that are naturally found in the human body including platelet-rich plasma (PRP), isolated growth factors, and cell therapy approaches to theoretically optimize and improve the healing of cartilage, fractures, and injured muscles, tendons, and ligaments.PRP is an autologous derivative of whole blood generated by centrifugation and is perhaps the most widely used orthobiologic treatment modality. Despite a vast amount of literature on its use in osteoarthritis as well as in tendon and ligament pathology, clinical efficacy results remain mixed, partly as a result of insufficient reporting of experimental details or exact compositions of PRP formulations used.Mesenchymal stromal cells (MSCs) can be isolated from a variety of tissues, with the most common being bone marrow aspirate concentrate. Similar to PRP, clinical results in orthopaedics with MSCs have been highly variable, with the quality and concentration of MSCs being highly contingent on the site of procurement and the techniques of harvesting and preparation.Advances in novel orthobiologics, therapeutic targets, and customized orthobiologic therapy will undoubtedly continue to burgeon, with some early promising results from studies targeting fibrosis and senescence.

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All-inside technique versus in situ transtendon repair for Ellman Ⅲ partial articular supraspinatus tendon avulsion

Yuan¹,

Yang²,

Qian³

et al. 2023

Journal of Shoulder and Elbow Surgery

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Immunologic Contributions Following Rotator Cuff Injury and Development of Cuff Tear Arthropathy

Cited by 3 publications

References 60 publications

Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears

Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears

Current State of Platelet-Rich Plasma and Cell-Based Therapies for the Treatment of Osteoarthritis and Tendon and Ligament Injuries

All-inside technique versus in situ transtendon repair for Ellman Ⅲ partial articular supraspinatus tendon avulsion

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