Immunologic “colitis” in dogs

Bicks, Richard O.; Walker, Richard

doi:10.1007/bf02236138

Cited by 19 publications

(3 citation statements)

References 19 publications

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“…The colon of the rabbit and dog has been shown to participate in the Arthus, Auer, and Schwartzman reactions (11), and in mucosal cell reactions (14). None of these has produced chronic, progressive lesions.…”

Section: Allergy and Hypersensitivitymentioning

confidence: 99%

“…However, colonic participation was passive and dependent upon generalized sensitization procedures followed by local antigen injections. Bicks and Walker (14) attempted to show that colonic mucosa was the antigen or that a systemic immunologic reaction could be localized in the colon without prior sensitization. They succeeded in producing an immunologic colitis in dogs by immunization with an anticolon rabbit serum administered intravenously.…”

Section: Allergy and Hypersensitivitymentioning

confidence: 99%

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Experimental Colitis

MacPherson¹,

Pfeiffer²

1976

Digestion

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Ulcerative colitis and Crohn’s disease are complex, problematic diseases of unknown etiology in man, and appropriate experimental models would be useful in elucidating their pathogenesis and treatment. Although there have been numerous attempts to produce inflammatory ulcerative colonic disease in laboratory animals resembling those human disease forms, none has been entirely successful. Investigators have conducted experiments involving almost every etiological factor suggested for initiation of these diseases. The methods reviewed in this paper include production of experimental colitis by vascular impairment, and immunological methods such as bacterial infection, allergic reactions, direct and indirect hypersensitivity reactions, as well as autoimmune mechanisms. The results of carrageenan-induced colitis, irradiation, dietary, and drug-induced techniques are also discussed and the frequency and nature of spontaneous colonic lesions in animals is summarized.

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Section: Allergy and Hypersensitivitymentioning

confidence: 99%

Section: Allergy and Hypersensitivitymentioning

confidence: 99%

Experimental Colitis

MacPherson¹,

Pfeiffer²

1976

Digestion

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“…So far a number of experimental models of ulcerative colitis have been devised [15][16][17][18][19][20], Sulfated polysaccha rides such as DS by means of their marked electronegativ ity and their osmotic charge disrupt the mucosal lining. Further, some experimental studies point out the possible involvement of the intestinal microflora and the trigger ing of local immunological disturbances [21] as well as the likelihood of cancer development after long-term DS sodium administration [22], Therefore, by virtue of such effects, when focusing our research on colonic mucosa membrane composition, we chose the above model.…”

Section: Discussionmentioning

confidence: 99%

Shark Fin Enriched Diet Prevents Mucosal Lipid Abnormalities in Experimental Acute Colitis

Marotta

Chui

Safran³

et al. 1995

Digestion

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Marine lipids contain eicosapentaenoic acid (EPA) which has anti-inflammatory effects. The aim of this research was to study, using the dextran sulfate induced acute colitis (AC) model, the effect of an EPA-rich shark fin supplemented diet on the mucosal lipid composition. The histology score increased in AC (p < 0.05), but only slightly in the EPA group. Similarly, colonic permeability to a intraluminally instilled water-soluble contrast medium significantly increased in the AC group, but not in EPA group. As compared with controls, the AC group showed lower levels of phosphatidylethanolamine, phosphatidylinositol, free fatty acid C20:5, and PL-FA C18:1 and C18:2 and higher levels of sphingomyelin, lysophosphatidylcholine, and C18:l and free fatty acid C20:4 (p < 0.01) after 2 and 7 days. In the EPA group sphinogmyelin and lysophosphatidylcholine slightly increased and free fatty acid C20:4 decreased (p < 0.05) after 7 days, and no PL-FA change occurred. This study confirms the protective properties of EPA-rich marine food. EPA-enriched diet is protecting the colonic mucosa from the early derangements of lipid components occurring in this experimental AC model. This effect is likely to contribute to maintain an effective mucosal lining barrier.

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DNCB Allergy in the Guinea Pig Colon

Rosenberg¹,

Fischer²

1964

Arch Dermatol

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Immunologic “colitis” in dogs

Cited by 19 publications

References 19 publications

Experimental Colitis

Experimental Colitis

Shark Fin Enriched Diet Prevents Mucosal Lipid Abnormalities in Experimental Acute Colitis

DNCB Allergy in the Guinea Pig Colon

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