Immunologic changes after transfusion of autologous or allogeneic buffy coat‐poor versus white cell‐reduced blood to patients undergoing arthroplasty. I. Proliferative T‐cell responses and the balance of helper and suppressor T cells

Abstract

Results of the present study confirm the hypothesis of impaired T-cell-mediated immunity after allogeneic transfusion.

Transfusion-Associated Microchimerism in Combat Casualties

“…There are increases in suppressor T-cell activity, cell-mediated lympholysis, and serum neopterin as well. 4 Similar immunologic and immunosuppressive effects have been seen in clinical studies. In patients undergoing surgery for colorectal cancer, both allogenic and autologous blood transfusions produce immune activation.…”

Immunomodulation Mechanisms following Transfusion of Allogeneic und Autologous Erythrocyte Concentrates

“…The combination of suppressed T-cell proliferation (mixed lymphocyte culture test; MLC test), diminished cytolytic effector reaction (cell-mediated lymphocytotoxicity; CML) with continuous release of sIL-2R, s-TNFr and neopterin can be interpreted as a persistent but ineffective immune response. The fact that this type of immunomodulation was also found after administering leukocyte-filtered erythrocyte concentrates advocates that, in addition to the absolute leukocyte count, the length of storage and thus the viability of contaminating leukocytes plays a decisive role [6,7].…”

Difference in autologous blood transfusion-induced inflammatory responses between acute normovolemic hemodilution and preoperative donation

“…Biological substances released from blood components during storage play important roles in these side effects [4][5][6]. For example, the cause of the febrile nonhemolytic transfusion reaction was previously attributed to the immune system's reaction against donor leukocytes.…”