Immunologic Changes After Bariatric Surgery: Is it A Trigger for Systemic Autoimmune Diseases?

Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism

“… 63 , 64 Thus, an increase in one-carbon donors following surgery may in part mediate both beneficial and deleterious effects on the immune system seen following this intervention. 65 For example, a negative effect on the clinical course of multiple sclerosis is described following bariatric surgery, 66 whereas methionine restriction was found to have a positive effect on this disease in pre-clinical models. 63 Likewise, SG was found to result in altered anti-cancer immunity, with a dampened anti-tumor immune response compared to weight-matched controls, but improved response to immune checkpoint blockade.…”