Immunologic biomarkers for bacterial meningitis

Yekani, Mina; Memar, Mohammad Yousef

doi:10.1016/j.cca.2023.117470

Cited by 6 publications

(4 citation statements)

References 150 publications

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“…2. By aetiology: bacterial [7,8] (meningococcal, pneumococcal, staphylococcal, etc. ); viral [9,10] (acute lymphocytic choriomeningitis, enterovirus Coxsackie, herpes, cytomegalovirus, etc.…”

Section: General Characteristics Of Meningeal Syndrome Classification...mentioning

confidence: 99%

“…2. За етіологією: бактеріальний [7,8] (менінгококовий, пневмококовий, стафілококовий та ін. ); вірусний [9,10] (гострий лімфоцитарний хоріоменінгіт, ентеровірусний Коксакі, герпетичний, цитомегаловірусний та ін.…”

Section: загальна характеристика менінгеального синдрому класифікація...unclassified

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Meningeal Syndrome: Diagnostic Algorithm, Treatment Tactics

Zdor,

Iziumska,

Lymarenko

et al. 2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 3 (170) / Bulletin of problems in biology and medicine -2023 -Issue 3 (170) 39 ОГЛЯДИ ЛІТЕРАТУРИ / LITERATURE REVIEWSIn particular, modern criteria for choosing a therapeutic strategy, the main problems that accompany therapy, and factors that affect patient compliance are analyzed by the authors.According to current guidelines, the first line therapy usually includes the administration of 5-aminosalicylic acid orally or rectally, followed by evaluation of clinical efficacy. In a case of insufficient effectiveness, almost all schemes involve corticosteroid's administration (topically or systemically depending on the severity of the disease). The main problem remains the high risk of glucocorticoids side effects. In case of ineffectiveness or insufficient effectiveness of steroid therapy or colectomy, second-line therapy may be recommended -calcineurin inhibitors (CsA, tacrolimus) and infliximab. It should be noted that, unfortunately, only about a quarter of patients respond to therapy with these medicines. The cytostatic methotrexate is also considered as a medication for therapy maintening in certain cases, especially in patients with intolerance to other immunosuppressants.In conclusion, nowadays, ulcerative colitis has a high prevalence in the population, which requires constant improvement of the medical correction ways. The latter is due to the fact that, despite the rather wide arsenal of medicines used for the ulcerative colitis therapy, they cannot provide effective and safe treatment of the disease in a number of cases. This dictates the urgent need to find and research new methods of pharmacotherapy.

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Section: General Characteristics Of Meningeal Syndrome Classification...mentioning

confidence: 99%

Section: загальна характеристика менінгеального синдрому класифікація...unclassified

Meningeal Syndrome: Diagnostic Algorithm, Treatment Tactics

Zdor,

Iziumska,

Lymarenko

et al. 2023

VPBM

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“…Meningitis is defined as the inflammation of the meninges that is most often caused by various bacterial and viral pathogens. It is associated with high rates of mortality and morbidity [1]. The most common sequela after bacterial meningitis is hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Cochlear Implants after Meningitis and Otosclerosis: A Comparison between Cochlear Ossification and Speech Perception Tests

Lamounier,

Carasek,

Daher

et al. 2024

JPM

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(1) Background: Performance after Cochlear Implantation (CI) can vary depending on numerous factors. This study aims to investigate how meningitis or otosclerosis can influence CI performance. (2) Methods: Retrospective analysis of CI performance in patients with etiological diagnosis of meningitis or otosclerosis, comparing the etiologies and analyzing the image findings, along with electrode array insertion status and technique. (3) Results: Speech recognition in CI patients with otosclerosis improves faster than in patients with meningitis. Other features such as radiological findings, degree of cochlear ossification, surgical technique used and total or partial insertion of electrodes do not seem to be directly related to speech recognition test performance. (4) Conclusions: Patients should be warned that their postoperative results have a strong correlation with the disease that caused their hearing loss and that, in cases of meningitis, a longer duration of speech–language training may be necessary to reach satisfactory results.

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“…The classic presentation of the disease includes symptoms such as fever, neck stiffness, headache, anorexia, vomiting, lethargy, and neuropsychological impairment, which affect up to 50% of survivors (1). Complications of meningitis include significant disabilities such as vision problems, deafness, seizures, and brain damage (2,3). While adults are less commonly affected, symptoms in children, immunocompromised individuals, the elderly, and those with chronic conditions are often less specific.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Diagnostic Significance of Neutrophil Percentage to Albumin Ratio (NPAR) in Patients with Infectious Meningitis

Bughio,

Depar,

Ghani

et al. 2024

JHRR

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Background: Meningitis, characterized by inflammation of the meninges, typically presents with fever, headache, and neck rigidity. Despite the availability of numerous diagnostic techniques, determining the etiology of infectious meningitis remains challenging, often leading to diagnostic delays and increased mortality. The neutrophil percentage-to-albumin ratio (NPAR) is a novel biomarker for systemic infection and inflammation. Objective: To assess the neutrophil-to-albumin ratio in cases of infectious meningitis. Methods: Following REC approval (05/01/REC-206-2020), this cross-sectional study included 78 patients with clinical findings consistent with meningitis. Data on age, gender, fever, headache, neck rigidity, and Glasgow Coma Scale (GCS) were collected. NPAR was calculated by dividing the neutrophil percentage by serum albumin levels. Statistical analysis was performed using SPSS 22.0 for T-test (two-tailed) and Pearson Correlation. Results were presented as mean±SD (95% CI) with a significance level of p<0.05. Results: The mean age of patients was 27 years. The mean GCS score was 11±1.59, serum albumin levels were 3.44±0.5 mg/dl, neutrophil percentage was 75.6±7.2%, and the neutrophil-to-albumin ratio (NPAR) was 0.22±0.03. Common symptoms such as fever, neck rigidity, and headache were present in all cases, while seizures were observed in 36 cases. Conclusion: The study indicated a significant correlation between elevated NPAR levels and cases of infectious meningitis, suggesting NPAR as a potential diagnostic marker.

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Immunologic biomarkers for bacterial meningitis

Cited by 6 publications

References 150 publications

Meningeal Syndrome: Diagnostic Algorithm, Treatment Tactics

Meningeal Syndrome: Diagnostic Algorithm, Treatment Tactics

Cochlear Implants after Meningitis and Otosclerosis: A Comparison between Cochlear Ossification and Speech Perception Tests

Investigating the Diagnostic Significance of Neutrophil Percentage to Albumin Ratio (NPAR) in Patients with Infectious Meningitis

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