Immunologic assessment of a cluster of asymptomatic HTLV-I-infected individuals in New Orleans

deShazo, Richard D.; Chadha, Naiyer; Morgan, Jane E.; Shorty, Vernon J.; Rangan, S. R. S.; Kalyanaraman, V. S.; Hyslop, Newton; Chapman, Yvonne; O'dea, Sean W.

doi:10.1016/0002-9343(89)90231-3

Cited by 22 publications

(6 citation statements)

References 27 publications

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“…4 These findings are in agreement with previous reports suggesting that suppressed cellular immunity in HTLV-I carriers, for example, leads to an increase in the prevalence of infectious diseases11 and the weakness of the tuberculin skin reaction 12. However, in some HTLV-I carriers there was no disturbance in T lymphocyte subsets 7. In the present study we could not find any differences in lymphocyte counts and T cell subsets in the peripheral blood lymphocytes.…”

Section: Discussionsupporting

confidence: 93%

“…Serovar 4 MAC infection is most common in AIDS4 and is known to be able to reduce the lymphocyte blastogenic response to concanavalin A (Con A) and phytohaemagglutinin (PHA) 5. In addition, there have been some reports regarding the immunological effects of HTLV-I on lymphocytes—for example, the effect on lymphocyte populations6 and the effect of PHA on T lymphocytes of asymptomatic HTLV-I infected individuals 7. This study was undertaken to compare the inhibitory effect of GPL on the lymphocyte blastogenic response to PHA in HTLV-I carriers and non-carriers and to clarify the immunological abnormality associated with MAC infection in HTLV-I carriers.…”

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confidence: 99%

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Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotrophic virus type I carriers

Matsuyama

Hamasaki²,

Mizoguchi³

et al. 2001

Thorax

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Background-We have previously reported that disseminated pulmonary Mycobacterium avium complex (MAC) infection is more common in human T lymphotrophic virus type I (HTLV-I) carriers than in non-carriers. However, the reason for this remains unclear. It has been shown that glycopeptidelipid (GPL), one of the lipid components of the cell envelope of MAC, is able to reduce the lymphocyte blastogenic response to mitogens. The purpose of this study was to clarify whether or not the inhibitory eVect of GPL diVers between HTLV-I carriers and non-carriers. Methods-Peripheral blood lymphocytes were obtained from 29 patients who had recovered from pulmonary MAC infection (10 of whom also had HTLV-I infection) and the lymphocyte counts and T cell subpopulations of the peripheral blood lymphocytes in HTLV-I carriers and noncarriers were compared. The inhibitory eVect of GPL on the lymphocyte blastogenic response to phytohaemagglutinin (PHA) was tested in these 29 cases and in 15 healthy controls who had never suVered from MAC (seven of whom also had HTLV-I infection). All HTLV-I positive cases were carriers. Results-There was no significant diVerence in the numbers or subset proportions of T cells between HTLV-I carriers and non-carriers. Lymphocyte activation by PHA was significantly inhibited by GPL in MAC positive and negative HTLV-I carriers compared with MAC negative noncarriers and MAC negative healthy controls (p<0.001). Conclusions-We suggest that MAC infection leads to strong inhibition of lymphocyte activation in HTLV-I carriers. This may account, in part, for the severity of pulmonary MAC infection in HTLV-I carriers.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotrophic virus type I carriers

Matsuyama

Hamasaki²,

Mizoguchi³

et al. 2001

Thorax

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“…These results are in general agreement with previous reports where CD4+CD29+ was found to be increased in ATL [21], HAM/TSP [22], and asymptomatic HTLV-I carriers [24]. In contrast to these studies, phenotypic analysis of non-HIV-infected i.v.…”

Section: Discussionsupporting

confidence: 93%

“…Small amounts of lytic activity were occasionaiiy observed in both infected and normal controls, suggesting the presence of NK activity in some of the cultures. Depressed NK activity and poor mitogenie responses in HTLV-infected individuals have been reported in previous studies [24,27]. Collectively, these results suggest that while the CD4+CD29+ population correlated with HTLV-specific antibody production, it may not be sufficient to provide stimulatory signal for generation of cytolytic activity.…”

Section: Discussionsupporting

confidence: 62%

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Concomitant augmentation of CD4+CD29+ helper inducer and diminution of CD4+CD45RA+ suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II

Lal

Rudolph

Schmid

et al. 1992

Clinical and Experimental Immunology

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SUMMARY To examine the immunomodulatory effects of HTLV infection, lymphocyte subset analysis was performed on patients infected with human T cell lymphotropic virus type‐I (HTLV‐I, n= 6) or ‐II (HTLV‐II, n= 12) and on normal blood donors (n= 16). The percentages of total B lymphocytes (CD19), natural killer (NK) cells (CDI6), T lymphocytes and their subsets (CD2, CD3, CD4, CD5, CD7, CDS), and IL‐2R (CD2S) were found to be within the range found in normal donors. However, the expression of CD8+ HLA‐DR+ increased significantly in patients with HTLV‐I or HTLV‐II infection (14.1 ± 3.9% and 9.7 ± 2.4% respectively; P<0.01) when compared with controls (3.2 ± 1.1%). In addition, there was a significantly greater proportion of CD4+ CD29+ T lymphocytes (29.3 ± 6.1% and 31.1 ± 9.0%; P<0.05) with concomitant diminution of CD4+CD45RA+ T lymphocytes (8.3 ± 3.3% and 11.4 ± 1.5%; P<0.01) in patients infected with HTLV‐I or HTLV‐II respectively, when compared with controls. The increased percentage of CD4+CD29+ subpopulations showed a direct correlation (rs=0.86; P<0.001) with HTLV‐specific antibody production. No difference in the CD8 population coexpressing CD29 and S6F1 (an epitope of LFA‐1) were observed in the HTLV‐infcctcd group when compared with normal donors and functional analysis exhibited minimal cytotoxicity against lectin labelled heterologous target cells. Thus, the shift in the suppressor/cytotoxic to helper/inducer‘memory’ CD4+ may be associated with immunoregulatory abnormalities often found in persons infected with HTLV‐I or HTLV‐II.

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Increased Incidence of Infectious Diseases During Prospective Follow-up of Human T-Lymphotropic Virus Type II– and I–Infected Blood Donors

Murphy

Glynn²,

Fridey³

et al. 1999

Arch Intern Med

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Immunologic assessment of a cluster of asymptomatic HTLV-I-infected individuals in New Orleans

Cited by 22 publications

References 27 publications

Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotrophic virus type I carriers

Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotrophic virus type I carriers

Concomitant augmentation of CD4+CD29+ helper inducer and diminution of CD4+CD45RA+ suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II

Increased Incidence of Infectious Diseases During Prospective Follow-up of Human T-Lymphotropic Virus Type II– and I–Infected Blood Donors

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