Immunologic Alterations in Patients with Sensorineural Hearing Disorders

Mayot, D.; Béné, Marie C.; Dron, K.; Perrin, C; Fauré, G

doi:10.1006/clin.1993.1092

Cited by 25 publications

(12 citation statements)

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“…Indeed, it has been postulated that the hearing loss is associated with autoimmunity (43). Positive anti-Tg antibodies and thyroid-stimulating antibodies were found in PS patients by Friis et al (44), and Mayot et al (45) reported anti-thyroid as well as anti-cochlear antibodies in a group of 40 patients with progressive SNHL, suggesting a link between autoimmune inner ear disease and autoimmune thyroid disease. More studies are needed to establish the importance of these observations, but we postulate that in the two families presenting with pseudo-Pendred, the hearing loss may be linked to the thyroid disorder on an autoimmune basis.…”

Section: Discussionmentioning

confidence: 89%

Differential Diagnosis between Pendred and Pseudo-Pendred Syndromes: Clinical, Radiologic, and Molecular Studies

et al. 2002

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Section: Discussionmentioning

confidence: 89%

Differential Diagnosis between Pendred and Pseudo-Pendred Syndromes: Clinical, Radiologic, and Molecular Studies

et al. 2002

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“…In 1964, more than 200 cases had been reported in the literature. Several authors have demonstrated the inadequacy of relying upon any one or combination of the characteristic facets of this syndrome in making an accurate diagnosis (Mayot, 1993). In 1958 the potassium perchlorate discharge proved to be a reliable diagnostic test for Pendred syndrome in individuals with congenital sensorineural deafness (Morgan & Trotter, 1958), and it seems that the test is still accepted by many as the gold standard for that purpose (Trotter, 1960).…”

Section: Discussionmentioning

confidence: 99%

Comparison of MRI findings with traditional criteria in diagnosis of Pendred syndrome

Sharghi

Haghpanah

Heshmat

et al. 2007

International Journal of Audiology

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Pendred syndrome, defined as the constellation of goiter, sensori-neural hearing loss, and positive perchlorate discharge test, is the most frequent cause of congenital deafness. Newly introduced diagnostic approaches to the disease are rather expensive and complicated, therefore we evaluated the value of MRI as the sole, or adjunctive diagnostic approach, and compared it with the traditional ones. Presuming the classic triad as the gold standard, we compared MRI findings in six such defined patients with six cases having goiter, hearing loss, and normal perchlorate discharge test. Our results indicated that MRI was 83.6% sensitive and 66.7% specific in patients fulfilling all three criteria (complete), while in the 'partial' group the sensitivity and specificity were 66.7% and 100% respectively. In conclusion, MRI, although impressive as an adjunctive diagnostic tool, may not replace the holistic approach, and the latter may be more convenient, cheaper, and still more accurate. However in 'partial' cases with equivocal findings, and in relatives of the patients, MRI may be a valuable diagnostic adjunct.

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“…Dr. Kinne's interpretation is largely based on Ki-67 staining using MIB-1 antibody. It has been shown that this antibody fails to label nonmitotic proliferating cells unless the tissue sections are treated with microwave irradiation (2). Since the technical details are not provided in Dr. Kinne's letter, we are unable to comment on the labeling efficiency of their method.…”

Section: To the Editormentioning

confidence: 93%