Immunolocalization of estrogen and androgen receptors and steroid concentrations in the stallion epididymis

Parlevliet, J. M.; Pearl, Christopher A.; Hess, Rex A.; Famula, Thomas R.; Roser, Janet F.

doi:10.1016/j.theriogenology.2005.12.013

Cited by 50 publications

(29 citation statements)

References 34 publications

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“…Hejmej et al (2005) also evaluated the intensity of the staining; although our findings were similar for ER␤, the intensity of the staining was stronger in the present than previous study. Findings in the present study differ from those of Parlevliet et al (2006) and Hejmej et al (2005) with respect to ER␣, because no immunostaining was found in the corpus and cauda of epididymides.…”

Section: Discussioncontrasting

confidence: 99%

“…These findings reinforce that estrogens are involved in epididymal function (Hess et al, 1997) and corroborate the findings of Parlevliet et al (2006) with respect to ER␤. Hejmej et al (2005) also evaluated the intensity of the staining; although our findings were similar for ER␤, the intensity of the staining was stronger in the present than previous study.…”

Section: Discussionsupporting

confidence: 87%

“…The importance of estrogens for proper epididymal function is most clearly demonstrated in estrogen receptor knockout mice which have significantly impaired fluid reabsorption from the efferent ducts, abnormal epididymal morphology and abnormal epididymal sperm (Eddy et al, 1996). Testosterone and estradiol may regulate the epididymal secretion of many proteins and other factors important for sperm maturation (Parlevliet et al, 2006). The present study investigated whether the stallion epididymis is an estrogen responsive tissue and also characterized changes in the localization of the estrogen receptor subtypes ␣ (ER␣) and ␤ (ER␤) among the different regions of the epididymis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical localization of estrogen α and β receptors in adult stallion epididymis

Martin¹,

Melo²,

Rodrigues³

et al. 2010

Animal Reproduction Science

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical localization of estrogen α and β receptors in adult stallion epididymis

Martin¹,

Melo²,

Rodrigues³

et al. 2010

Animal Reproduction Science

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“…The PDIp-bound estrogen can help augment estrogen receptor-mediated transcriptional activity (Fu and Zhu 2009a). Since pancreas (Morales-Miranda et al 2007), stomach (Sakata et al 2006), adrenal glands (Young et al 2006), prostate (Ellem and Risbridger 2007), and epididymis (Parlevliet et al 2006;Pearl et al 2007) are all considered to be estrogen-sensitive organs, the expression of PDIp in these organs suggests that it may function as a modulator of the estrogenic activity at these target sites. In this context, it is also of interest to suggest that the very high levels of PDIp expressed in estrogen-producing cells in the zona fasciculate of the adrenal cortex may serve as an intracellular protein for binding and storing estrogens.…”

Section: Discussionmentioning

confidence: 99%

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions

Dai

Ding

et al. 2009

J Mol Hist

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Members of the protein disulfide isomerase (PDI) family play a critical role in catalyzing the formation of disulfide bonds in secretory proteins, and most of these enzymes have a wide tissue distribution. However, the pancreas-specific PDI homolog was previously suggested to be exclusively expressed in the pancreas (thus commonly referred to as PDIp). In the present study, we found that PDIp was also highly expressed in several other tissues in mice, including the stomach, cecum, ileum, adrenal glands, epididymis, and prostate. Notably, in the digestive organs, such as the stomach and pancreas, very high levels of PDIp were selectively expressed in the digestive enzyme-secreting cells (e.g., gastric chief cells and pancreatic acinar cells). This observation suggests that PDIp may function as a protein-folding catalyst for secretory digestive enzymes. In ileum, PDIp was exclusively expressed in Paneth cells. In addition, high levels of PDIp expression were also detected in normal human pancreas, but its expression was mostly absent in human pancreatic duct adenocarcinoma and pancreatic cancer cell lines. The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer.

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“…In stallions, androgen receptors are distributed throughout the reproductive tract (in the testis, epididymis, and prostate: Bilinska et al, 2005), whereas estrogen receptor distribution is both age and tissue/segment dependent (Parlevliet et al, 2006). Dihydrotestosterone may be produced locally within the epididymis because the principal cells, particularly in the initial segment of the epididymis, contain 5␣-reductase (Robaire and Viger, 1995).…”

Section: Structure Of the Epididymal Ductmentioning

confidence: 99%

The roles of the epididymis and prostasomes in the attainment of fertilizing capacity by stallion sperm

Šoštarić

Aalberts

Gadella

et al. 2008

Animal Reproduction Science

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The epididymis is a long, tightly coiled tube within the lumen of which sperm matures. Sperm maturation involves morphological and biochemical changes in the sperm plasma membrane in response to epididymal secretions and their various proteins. Some of these proteins become outer membrane components while others become integral membrane proteins; transfer of some proteins to the sperm plasma membrane may be mediated by epididymosomes. Nevertheless, the molecular pathways by which spermatozoa acquire fertilizing capacity during their transit through the epididymis remain ambiguous. In a recent study of stallion epididymal sperm, we found that sperm harvested from different parts of the epididymis (caput, corpus and cauda) had a varying, but generally poor, ability to undergo the acrosome reaction in vitro. At ejaculation, however, sperm mix with seminal plasma which contains various components, including the small membranous vesicles known as prostasomes, that may enable the sperm to undergo physiological activation. Seminal plasma components may have a 'washing' effect and help to remove 'de-capacitation' factors that coat the sperm during storage in the cauda epididymis; alternatively seminal plasma and prostasomes may contain factors that more directly promote sperm activation. This article reviews current information ଝ This paper is part of the Special issue entitled "Proceedings of the 5th International Symposium on Stallion Reproduction", Guest edited by Terttu Katila.* Corresponding author. Author's personal copy 238 E. Sostaric et al. / Animal Reproduction Science 107 (2008) 237-248 on the roles of epididymal and accessory gland fluids on the acquisition of fertilizing capacity by stallion sperm.

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Immunolocalization of estrogen and androgen receptors and steroid concentrations in the stallion epididymis

Cited by 50 publications

References 34 publications

Immunohistochemical localization of estrogen α and β receptors in adult stallion epididymis

Immunohistochemical localization of estrogen α and β receptors in adult stallion epididymis

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions

The roles of the epididymis and prostasomes in the attainment of fertilizing capacity by stallion sperm

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