Immunolocalization of adenomatous polyposis coli protein (apc) in the regenerating lizard tail suggests involvement in tissue differentiation and regulation of growth
Abstract:Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is the “adenomatous polyposis coli (apc)” but the localization of its coded protein (apc) is not known. This protein may be involved in regulation of apical‐basal tail regeneration in lizards. The present immunohistochemical study shows that apc is localized in apical wo… Show more
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