Immunokinases

Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins

“…Immunokinase fusion proteins are entirely made up of a targeting moeity specific for an unregulated surface marker on cancer cells and an effector domain capable of inducing a therapeutic benefit in tumor cells lacking kinase activity. In most cases, the targeting moeity is a single chain antibody fragment (scFv) genetically fused to a constitutively active mutant of a tumor suppressor kinase ( Figure 4 ) [ 75 ]. Unlike the demethylating agents described above, immunokinase based fusion protein combine systemic targeted delivery and targeted activity to prevent off-target effects in normal cells expressing target antigens at physiological levels [ 75 ].…”

“…In most cases, the targeting moeity is a single chain antibody fragment (scFv) genetically fused to a constitutively active mutant of a tumor suppressor kinase ( Figure 4 ) [ 75 ]. Unlike the demethylating agents described above, immunokinase based fusion protein combine systemic targeted delivery and targeted activity to prevent off-target effects in normal cells expressing target antigens at physiological levels [ 75 ]. They are also entirely made up of human component, hence are not limited by immunogenicity drawbacks that affect the bacteria based fusion proteins.…”