Immunoinformatic Responses of Host MHC I/II and CD4+ Cells Against Conserved Spike Fragments of SARS CoV-2 of 186 Countries With In-Silico Mutations: Implications in Universal Vaccination
Abstract:Different types of quickly-developed vaccines have been introduced against Covid-19 with largely inconclusive results. On the course of time, somewhere Covid-19 declines its infection/mortality rate and in some countries it revived with some new mutant-variants. Considering the large number of global variants, in the current study several conserved (186 countries) sequences (checked by ClustalX2) epitopic regions (by SVMTriP and IEDB) and in-silico mutants of SARS CoV-2 spike protein fragments (Cut 1-4) were s… Show more
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