Immunohistology of Soft Tissue and Osseous Neoplasms

Cerilli, Lisa A.; Wick, Mark R.

doi:10.1016/b978-0-443-06652-8.50009-0

Cited by 33 publications

(47 citation statements)

References 360 publications

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“…4,12 Evidence for that contention is relatively complete regarding host cells in granulomas where morphologic and immunohistochemical data indicate their identity as macrophages. Though encysted host cells have similar morphologic features and have been identified by others to be macrophages, 7 they did not react with the macrophage marker, MAC 387.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Stages ofHepatozoon americanumand of Parasitized Canine Host Cells

et al. 2005

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Abstract. American canine hepatozoonosis is caused by Hepatozoon americanum, a protozoan parasite, the definitive host of which is the tick, Amblyomma maculatum. Infection of the dog follows ingestion of ticks that harbor sporulated H. americanum oocysts. Following penetration of the intestinal mucosa, sporozoites are disseminated systemically and give rise to extensive asexual multiplication in cells located predominantly in striated muscle. The parasitized canine cells in ''onion skin'' cysts and in granulomas situated within skeletal muscle, as well as those in peripheral blood leukocytes (PBL), were identified as macrophages by use of fine structure morphology and/or immunohistochemical reactivity with macrophage markers. Additionally, two basic morphologic forms of the parasite were observed in macrophages of granulomas and PBLs. The forms were presumptively identified as merozoites and gamonts. The presence of a ''tail'' in some gamonts in PBLs indicated differentiation toward microgametes. Recognition of merozoites in PBLs supports the contention that hematogenously redistributed merozoites initiate repeated asexual cycles and could explain persistence of infection for long periods in the vertebrate host. Failure to clearly demonstrate a host cell membrane defining a parasitophorous vacuole may indicate that the parasite actively penetrates the host cell membrane rather than being engulfed by the host cell, as is characteristic of some protozoans.

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Section: Discussionmentioning

confidence: 99%

Characterization of Stages ofHepatozoon americanumand of Parasitized Canine Host Cells

et al. 2005

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“…It is very difficult to establish a panel series comprising each possibility in this topic. The panels which may be used according to localization have been provided below only as recommendation [26][27][28].…”

Section: Ihc Markers Used For Diagnostic Purposementioning

confidence: 99%

Role of Pathologist in Driver of Treatment of CNS Tumors

Altınay¹

2017

New Approaches to the Management of Primary and Secondary CNS Tumors

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The incidence of Central Nervous System (CNS) tumors is gradually increasing. Furthermore, metastatic neoplasms are frequently seen in neuropathology practice as a major cause of mortality and morbidity. Pathologists try to reach a more accurate diagnosis by mentally filtering a synthesis, comprising age, radiological characteristics and microscopic findings in the sample sent, starting already from the intraoperative diagnosis process. By displaying their skills, they unveil whether a lesion in the brain parenchyma is a normal or reactive tumor and if this is a tumor, is it primary or metastatic, and if it is primary, what is the tumor type or if it is metastatic, which organ could it be associated with. Pathologists use diagnostic, prognostic and predictive markers in order to enable the patient receive the most effective and sufficient treatment. They ensure that an individualized treatment is provided via these tools, by making a histological diagnosis of the lesion according to the WHO classification, identifying the course of the disease and preventing undesired and dangerous complications. This chapter will focus on answering these questions and share the value of a multidisciplinary approach in the management of brain tumors in neurosciences, which is gradually increasing in importance, and how pathologists execute this art.

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“…With the development of immunohistochemistry, the type of soft tissue tumor was divided more specifically based on the subtle distinction of their differentiation. Note, however, that such histochemical method is an additional tool for histomorphologic evaluation (microscopic examination), not a substitution 14 .…”

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confidence: 99%

Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts

Kim

Choi

Kim

2012

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2012;38:78-84) Objectives: Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17. Results: CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P<0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P<0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P<0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P<0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P<0.05). Conclusion: The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.

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Immunohistology of Soft Tissue and Osseous Neoplasms

Cited by 33 publications

References 360 publications

Characterization of Stages ofHepatozoon americanumand of Parasitized Canine Host Cells

Characterization of Stages ofHepatozoon americanumand of Parasitized Canine Host Cells

Role of Pathologist in Driver of Treatment of CNS Tumors

Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts

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