“…Gangliosides are glycosphingolipids containing sialic acids and are present in almost all cell types. The exact biological function of gangliosides is still unknown, but they have been considered as melanoma-associated antigens and targets for antibody-based and vaccine-based therapies of melanoma (Houghton et al, 1985;Livingston et al, 1987;Ota et al, 1995). Vaccination of certain gangliosides elicit anti-ganglioside antibodies in melanoma patients and mice.…”