Immunohistological analysis of P53 expression in human skin tumors

Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: Prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations

“…Several lines of accumulating evidence show a considerable variation of p53 protein expression in skin lesions, with reported frequencies of 0% to 80% in AK and BD and from 0% to 92% in SCC. 18,[46][47][48][49][50][51][52][53][54][55] Although, in our study, PCNA expression in PD was relatively higher than that in CR groups, there were no significant differences. Moreover, p53 expression varied between CR and PD groups.…”

p53 Oncoprotein Expression in Cutaneous Lymphoproliferations

“…Therefore, our results confirm previous findings on very limited series. 15,16 Pleomorphic T-cell lymphomas did not express a detectable level of p53 protein with medium and large cells (high grade) or with small cells (low grade). p53 overexpression has been described in nodal anaplastic lymphomas,26,27 but Cesarman et al26 have found a p53 gene mutation in only one of 12 p53-positive cases of ALCL.…”

Cell cycle and apoptosis regulators in Spitz nevi: Comparison with melanomas and common nevi

“…19 In general p-53 expression in melanomas has been largely conflicting with the reported prevalence of immunoreactivity ranging from 0% to 97%, 20 whereas it has been found consistently minimal in common nevi. 21 The parallel expression of p-53 and p-21 proteins observed in all p-53 positive cases implies that p-53 is wild-type and its induction could be explained by UV exposure of the skin before biopsy or by unknown stress conditions or inherent nevocellular factors, which have necessitated p-53 mediated DNA repair. Interestingly, in all cases demonstrating p-53 expression 5% to 10%, a higher than average proliferation rate was detected (Ki-67 5%-10%).…”