Immunohistologic Findings and Results of Treatment with Cyclosporine in Ligneous Conjunctivitis

Holland, Edward J.; Chan, Chi‐Chao; Kuwabara, Toichiro; Palestine, Alan G.; Rowsey, J. James; Nussenblatt, Robert B.

doi:10.1016/0002-9394(89)90216-x

Cited by 91 publications

(52 citation statements)

References 9 publications

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“…Most affected children are healthy at birth and develop ligneous conjunctivitis during the first weeks or months of life. It has been suggested that minor trauma or infection of the conjunctival epithelium may initiate the development of this disorder (Holland et al, 1989;Weinstock and Kielar, 1975). Histological examination of pseudo-membranes from affected eyes or mucosa tissue from the genital tract exhibits a disrupted epithelium which is replaced by a massive deposition of fibrin and amorphous hyalin-like eosinophilic material and accompanied by an inflammatory cellular infiltration.…”

Section: Introductionmentioning

confidence: 99%

Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus

Schuster¹,

Seidenspinner²,

Müller³

et al. 1999

Prenat. Diagn.

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Section: Introductionmentioning

confidence: 99%

Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus

Schuster¹,

Seidenspinner²,

Müller³

et al. 1999

Prenat. Diagn.

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“…Konjonktival epitelde ülserasyon veya hiperplastik değişiklikler izlenebilir. 1,6,7 Nadir görülen, genellikle remisyon ve nükslerle uzun bir klinik seyir gösteren lignöz konjonktivitte kabul görmüş etkin bir tedavi protokolü bulunmamaktadır. Oluşan membran ve/veya kitlelerin cerrahi eksizyonu uygun topikal ve/veya sistemik tedavi önlemleri alınmadığında kısa zamanda nüksle sonuçlanmaktadır.…”

Section: Discussionunclassified

Lignöz Konjonktivit: Olgu Serisi

Özçura¹,

Yıldırım²,

Başmak³

et al. 2013

tjo

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Sum maryLigneous conjunctivitis is a rare form of chronic pseudomembranous conjunctivitis characterized by membranes on the conjunctiva. The disease usually affects children but can occur at older age as well. Similar lesions may develop on other mucous membranes of the body if the disease is associated with systemic plasminogen deficiency. We report our 6 cases with ligneous conjunctivitis and discuss them in terms of diagnosis, treatment, and prognosis. (Turk J Ophthalmol 2013; 43: 458-63)

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“…Besides oral and intravenous administration, intraperitoneal, subconjunctival and retrobulbar applications have been reported in animal studies [22,23]. Recently, successful results have been reported after local CsA application in high-risk keratoplasty [24], ligneous conjunctivitis [25], vernal conjunctivitis [26], atopic keratoconjunctivitis [6], Mooren's ulcer [27], secondary Sjögren syndrome [28] and keratoconjunctivitis sicca [29].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cyclosporin A on Cultured Rabbit Subconjunctival Fibroblast Proliferation

Bağcı

Yücel²,

Duranoğlu³

1999

Ophthalmologica

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The aim of this study was to examine the possible effects of local application of a potent immunosuppressive drug, cyclosporin A (CsA), on fibroblast proliferation in vitro. Rabbit subconjunctival fibroblasts were cultured and incubated with varying doses of CsA (from 0.5 to 5%). Growth inhibition curves were obtained, and cell attachment and reversibility of drug-induced growth inhibition were studied. None of the doses stimulated fibroblast proliferation. CsA inhibited fibroblast proliferation depending on the dose and duration of application. Also, drug-induced growth inhibition decreased depending on dose and duration of application. While the dosage which led to 50% inhibition was found to be 7.2 mg/ml, 4% and higher doses had toxic effects.

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Immunohistologic Findings and Results of Treatment with Cyclosporine in Ligneous Conjunctivitis

Cited by 91 publications

References 9 publications

Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus

Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus

Lignöz Konjonktivit: Olgu Serisi

The Effect of Cyclosporin A on Cultured Rabbit Subconjunctival Fibroblast Proliferation

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