Immunohistologic examination of pedicled autologous pericardium 9 years after implantation for an extracardiac conduit in Fontan pathway: Comparison with in situ pericardium and pulmonary arterial tissue from the same patient

Abstract

patients with single ventricular morphology and a large enough MPA for translocation, because it might be difficult to reconstruct the right ventricular outflow tract for biventricular repair after this technique. ConclusionsThis technique is simple and applicable, providing excellent midterm results because of the continuity of autologous pulmonary arterial tissue. References 1. Elzega NJ, von Suylen RJ, Frohn-Mulder I, Essed CE, Bos E, Quaegebeur JM. Juxtaductal pulmonary artery coarctation. An underestimated cause of branch pulmonary artery stenosis in patients with pulmonary atresia or stenosis and a ventricular septal defect.

Aortic valve replacement with autologous pericardium: long-term follow-up of 15 patients and in vivo histopathological changes of autologous pericardium

“…An important finding of this study was that an elastic band, which generally exists in the aortic valve and is not observed in fresh pericardial tissue, was found in the APAVs. A similar finding was also reported in a pedicled autologous pericardium 9 years after implantation for an extracardiac conduit in the Fontan pathway [22]. These results suggest that the autologous pericardium transplants may adapt to new environmental demands, in which the pericardium has transformed from its norm into the structure of the natural valve and vascular tissue after it is used for that purpose.…”

Implanted pedicled autologous pericardium mimics vasculature tissue: Case report

“…5 This finding was similar to that seen in PAP implanted for Fontan conduit repair. 4 On the other hand, the new emergence of smooth muscle cells was not previously described for PAP used for Fontan conduit repair, 4 but was similar to findings reported for nonpedicled pericardium implanted for RVOT. 5 The mechanism for transition of the pericardial tissue structure into the vascular wall structure was unclear; however, progenitor cells mobilized from the blood might differentiate into smooth muscle cells under the influence of the surrounding environment.…”

“…This report describes for the first time the long-term fate of implanted PAP used for RVOTR. Some investigations have demonstrated preservation of PAP viability when used in a low-pressure-circumference Fontan pathway 4 ; however, there currently are no clinical reports describing PAP viability when used in RVOTR, which is in a moderate-pressure circumference.…”

Hepatic to azygos connection by autologous pericardial roll for Fontan completion

“…5 Immunohistologic examination showed the presence of endothelium and the absence of calcification and fibrosis 9 years after a pedicled autologous pericardium implantation. 6 We believe that an isolated autologous pericardium might also be an ideal material. Although the isolated autologous pericardium lacked the growth potential, it might require a shorter period of anticoagulation treatment than what is needed for artificial prosthetic materials.…”

“…Reports have surfaced that favour the pedicled autologous pericardial roll as an ideal option for an extracardiac conduit. 5,6 In vivo, the conduit has the potential to grow in a parallel manner with somatic development. 5 Immunohistologic examination showed the presence of endothelium and the absence of calcification and fibrosis 9 years after a pedicled autologous pericardium implantation.…”