Immunohistochemistry using antibodies to the cathelicidin LL37/hCAP18 in the tammar wallaby, Macropus eugenii

Carman, Rebecca L.; Simonian, Mary; Old, Julie M.; Jacques, Nicholas A.; Deane, Elizabeth M.

doi:10.1016/j.tice.2008.05.002

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…Early studies on some innate mechanisms, including the composition of the blood of pouch young (Block, 1964;Yadav, 1972;Basden, 1996), the composition of the commensal flora of the gut (Lentle, 2006;Chhour et al, 2010), expression of HLA-DR in the skin of newborn opossums (Coutinho et al, 1995) and the expression of antimicrobial peptides (Carman et al, 2008(Carman et al, , 2009Daly et al, 2008) has laid the foundation for our current understanding of the development of innate immune protection in pouch young marsupials. Further, research on the timing of the development of the innate immune system and early immune protection in marsupials is required.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of antimicrobial peptides in the skin of developing pouch young has been examined in the tammar wallaby (Carman et al, 2008(Carman et al, , 2009Daly et al, 2008;Wang et al, 2011). Antimicrobial peptides, including a class of molecules known as cathelicidins are an important part of the innate immune system of mammals (Scott and Hancock, 2000).…”

Section: Skinmentioning

confidence: 99%

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The development of the immune tissues in marsupial pouch young

Borthwick

Young

Old

2014

Journal of Morphology

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Current knowledge of the development of the marsupial immune system, particularly in the context of lymphoid tissue development and the appearance of lymphocytes, has been examined and limitations identified. While primary lymphoid tissues like the thymus have been extensively studied, secondary lymphoid tissues such as the spleen and lymph nodes have been examined to a lesser extent, partly due to the difficulty of macroscopically identifying these structures, particularly in very small neonates. In addition, little research has been conducted on the mucosal-associated lymphoid tissues; tissues that directly trap antigens and play an important role in the maturity of adaptive immune responses. Research on the development of the marsupial immune tissues to date serves as a solid foundation for further research, particularly on the mechanisms behind the development of the immune system of marsupials. With the recent sequencing and annotation of whole marsupial genomes, the current wealth of sequence data will be essential in the development of marsupial specific reagents, including antibodies, that are required to widen our specific knowledge of the complex marsupial immune system and its development.

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Section: Discussionmentioning

confidence: 99%

Section: Skinmentioning

confidence: 99%

The development of the immune tissues in marsupial pouch young

Borthwick

Young

Old

2014

Journal of Morphology

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“…Cathelicidins, a type of antimicrobial peptide, found in most vertebrates are also produced by marsupials (Carman et al 2009;Carman et al 2008;Johnson et al 2018) and have been identified in milk (Daly et al 2008;Wanyonyi et al 2011). Warren et al (2008) have also identified cathelicidins (Whittington et al 2008a;2008b) and defensins in the platypus genome, and Whittington et al (2009) in the tissues (brain, kidney, liver, lung, spleen and testis), but did not find cathelicidins or defensins in platypus milk.…”

Section: Milk Aids Immunological Defense Of the Youngmentioning

confidence: 96%

Peer Review #1 of "Marsupial and monotreme milk—a review of its nutrient and immune properties (v0.1)"

2020

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All mammals are characterized by the ability of females to produce milk. Marsupial (metatherian) and monotreme (prototherian) young are born in a highly altricial state and rely on their mother's milk for the first part of their life. Here we review the role and importance of milk in marsupial and monotreme development. Milk is the primary source of sustenance for young marsupials and monotremes and its composition varies at different stages of development. We applied nutritional geometry techniques to a limited number of species with values available to analyze changes in macronutrient composition of milk at different stages. Macronutrient energy composition of marsupial milk varies between species and changes concentration during the course of lactation. As well as nourishment, marsupial and monotreme milk supplies growth and immune factors. Neonates are unable to mount a specific immune response shortly after birth and therefore rely on immunoglobulins, immunological cells and other immunologically important molecules transferred through milk. Milk is also essential to the development of the maternal-young bond and is achieved through feedback systems and odor preferences in eutherian mammals. However, we have much to learn about the role of milk in marsupial and monotreme mother-young bonding. Further research is warranted in gaining a better understanding of the role of milk as a source of nutrition, developmental factors and immunity, in a broader range of marsupial species, and monotremes.

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“…Cathelicidins, a type of antimicrobial peptide, found in most vertebrates are also produced by marsupials (Carman et al, 2009(Carman et al, , 2008Johnson et al, 2018) and have been identified in milk (Daly et al, 2008;Wanyonyi et al, 2011). Warren et al (2008) have also identified cathelicidins (Whittington et al, 2008a(Whittington et al, , 2008b and defensins in the platypus genome, and Whittington et al (2009) in the tissues (brain, kidney, liver, lung, spleen and testis), but did not find cathelicidins or defensins in platypus milk.…”

Section: Milk Aids Immunological Defense Of the Youngmentioning

confidence: 99%

Marsupial and monotreme milk—a review of its nutrient and immune properties

Stannard

Miller

Old

2020

PeerJ

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All mammals are characterized by the ability of females to produce milk. Marsupial (metatherian) and monotreme (prototherian) young are born in a highly altricial state and rely on their mother’s milk for the first part of their life. Here we review the role and importance of milk in marsupial and monotreme development. Milk is the primary source of sustenance for young marsupials and monotremes and its composition varies at different stages of development. We applied nutritional geometry techniques to a limited number of species with values available to analyze changes in macronutrient composition of milk at different stages. Macronutrient energy composition of marsupial milk varies between species and changes concentration during the course of lactation. As well as nourishment, marsupial and monotreme milk supplies growth and immune factors. Neonates are unable to mount a specific immune response shortly after birth and therefore rely on immunoglobulins, immunological cells and other immunologically important molecules transferred through milk. Milk is also essential to the development of the maternal-young bond and is achieved through feedback systems and odor preferences in eutherian mammals. However, we have much to learn about the role of milk in marsupial and monotreme mother-young bonding. Further research is warranted in gaining a better understanding of the role of milk as a source of nutrition, developmental factors and immunity, in a broader range of marsupial species, and monotremes.

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Immunohistochemistry using antibodies to the cathelicidin LL37/hCAP18 in the tammar wallaby, Macropus eugenii

Cited by 8 publications

References 30 publications

The development of the immune tissues in marsupial pouch young

The development of the immune tissues in marsupial pouch young

Peer Review #1 of "Marsupial and monotreme milk—a review of its nutrient and immune properties (v0.1)"

Marsupial and monotreme milk—a review of its nutrient and immune properties

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