Immunohistochemical tracking of an immune response in mammary Paget’s disease

Brunhuber, Thomas; Haybaeck, Johannes; Schäfer, Georg; Mikuz, Gregor; Langhoff, E; Saeland, Sem; Lebecque, Serge; Romani, Nikolaus; Obrist, Peter

doi:10.1016/j.canlet.2008.07.028

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…As far as we know, no previous studies have reported that this disease may be more common in the first years following a childbirth. Consistent with previous suggestions [45,46], most women diagnosed with Paget disease in the present study had an underlying tumor of ductal type. The tumor is often high grade and estrogen and progesterone receptor negative [45,47], and has been found to be positive also for other molecular markers that are frequently associated with more aggressive tumor behavior [47].…”

Section: Discussionsupporting

confidence: 93%

“…The tumor is often high grade and estrogen and progesterone receptor negative [45,47], and has been found to be positive also for other molecular markers that are frequently associated with more aggressive tumor behavior [47]. A high degree of inflammatory infiltrate in tumor-surrounding tissue has also been noted [46]. It has previously been suggested that inflammation-like processes in connection with the rebuilding of breast tissue after pregnancy and lactation may play a role for growth and spread of breast cancer tumors [48,49].…”

Section: Discussionmentioning

confidence: 99%

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Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway

2010

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BackgroundSome studies have indicated that reproductive factors affect the risk of histological types of breast cancer differently. The long-term protective effect of a childbirth is preceded by a short-term adverse effect. Few studies have examined whether tumors diagnosed shortly after birth have specific histological characteristics.MethodsIn the present register-based study, comprising information for 22,867 Norwegian breast cancer cases (20-74 years), we examined whether histological type (9 categories) and grade of tumor (2 combined categories) differed by parity or age at first birth. Associations with time since birth were evaluated among 9709 women diagnosed before age 50 years. Chi-square tests were applied for comparing proportions, whereas odds ratios (each histological type vs. ductal, or grade 3-4 vs. grade 1-2) were estimated in polytomous and binary logistic regression analyses.ResultsDuctal tumors, the most common histological type, accounted for 81.4% of all cases, followed by lobular tumors (6.3%) and unspecified carcinomas (5.5%). Other subtypes accounted for 0.4%-1.5% of the cases each. For all histological types, the proportions differed significantly by age at diagnoses. The proportion of mucinous and tubular tumors decreased with increasing parity, whereas Paget disease and medullary tumors were most common in women of high parity. An increasing trend with increasing age at first birth was most pronounced for lobular tumors and unspecified carcinomas; an association in the opposite direction was seen in relation to medullary and tubular tumors. In age-adjusted analyses, only the proportions of unspecified carcinomas and lobular tumors decreased significantly with increasing time since first and last birth. However, ductal tumors, and malignant sarcomas, mainly phyllodes tumors, seemed to occur at higher frequency in women diagnosed <2 years after first childbirth. The proportions of medullary tumors and Paget disease were particularly high among women diagnosed 2-5 years after last birth. The high proportion of poorly differentiated tumors in women with a recent childbirth was partly explained by young age.ConclusionOur results support previous observations that reproductive factors affect the risk of histological types of breast cancer differently. Sarcomas, medullary tumors, and possible also Paget disease, may be particularly susceptible to pregnancy-related exposure.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway

2010

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“…Therefore, it is more likely that mature DCs primarily capture tumorrelated antigens and process and present them to T lymphocytes for recruitment of other lymphocytes (7). Brunhuber et al, Ambe et al and Becker have reported that the amounts of tumor-infiltrating DCs and lymphocytes are interrelated in various tumors, such as melanoma, thyroid, esophageal, gastric and rectal cancers (18,29,30).…”

Section: Epithelium -------------------------------------------------mentioning

confidence: 99%

“…By contrast, it has been reported that fascin + tumor epithelium has strong invasiveness with poorer prognosis in various carcinomas, such as ovarian, breast, pancreas, lung, cutaneous, brain, gastrointestinal, thyroid, prostate, urothelial, intrahepatic cholangiocarcinoma and skin tumors (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). The significance of epithelial fascin expression has been reported to be associated with invasiveness and metastasis, since it aids in cell migration and proliferation through increases in lamellipodial and filopodial cell protrusions (15).…”

Section: Epithelium -------------------------------------------------mentioning

confidence: 99%

“…In normal adult human tissues, fascin expression is restricted to neurons and DCs; both cell types have markedly large filopodia and are highly motile (11,13). Fascin expression in various neoplastic cells has also been investigated, and its expression has been reported to be associated with epithelial to mesenchymal progression and invasion of tumor cells as well as a clinically aggressive manifestation and poorer prognosis (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). However, to the best of our knowledge, immunohistochemical studies for the detection of fascin + mature DCs in thymoma have yet to be performed.…”

Section: Introductionmentioning

confidence: 99%

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Fascin expression in dendritic cells and tumor epithelium in thymoma and thymic carcinoma

et al. 2011

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Abstract. The majority of thymomas are histologically characterized by tumor-infiltrating lymphocytes. Mature dendritic cells (DCs) are known to assemble lymphocytes through antigen presentation to T lymphocytes. Fascin, a 55-kDa actin-binding protein and a known marker for mature DCs, regulates filaments necessary for the formation of filopodia in cell migration. Moreover, fascin expression in various epithelial neoplasms has recently been reported to be associated with invasion of tumor cells and clinically aggressive manifestations. In the present study, we investigated fascin expression immunohistochemically in tissues of thymomas and thymic carcinomas surgically resected at our institute. A total of 34 thymomas and 5 thymic carcinomas were included. The amount and immunohistochemical intensity of both fascin + DCs and tumor epithelium were counted and assessed, and the clinicopathological data were also scored. Statistical analyses revealed that the amount of fascin + DCs with the formation of clusters was associated with lymphocyte-rich variants (p=0.002) and cortical differentiation (p=0.037) of thymoma with complication from myasthenia gravis (p=0.002). The quantity of fascin + epithelium was associated with a strong intensity of fascin in infiltrating DCs (p=0.002) with the formation of clusters (p=0.002) and favorable prognosis, as assessed by the Masaoka staging system (p=0.001). The amount of infiltrating DCs (p=0.024) and fascin + epithelium were lower in thymic carcinoma. It was concluded that fascin + epithelium may induce tumor immunity through the surveillance activity of fascin + DCs in thymic neoplasms, thus improving prognosis.

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BRCA1 Polymorphisms and Breast Cancer Epidemiology in the Western New York Exposures and Breast Cancer (WEB) Study

Ricks-Santi¹,

Nie

Marian

et al. 2013

Genetic Epidemiology

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Results of studies for the association of BRCA1 genotypes and haplotypes with sporadic breast cancer have been inconsistent. Therefore, a candidate SNP approach was used in a breast cancer case-control study to explore genotypes and haplotypes that have the potential to affect protein functions or levels. In a breast cancer case-control study, genotyping of BRCA1 polymorphisms Q356R, D693N, and E1038G was performed on 1005 cases and 1765 controls. Unconditional, polytomous logistic regression and chi square tests were used to examine the associations of breast cancer with genotypes and haplotypes. Additionally, interactions between genotype and smoking, benign breast disease, family history of breast cancer, BMI, alcohol consumption, and hormonal risk factors, hormone receptor status, and breast cancer pathology were calculated also using logistic regression and chi square. While, sporadic breast cancer was not associated with BRCA1 genotypes or haplotypes overall or by menopausal status, there was evidence of an interaction between the E1038G BRCA1 genotype, smoking, and BMI among premenopausal women (p for interaction=0.01 and 0.045, respectively) and between E1038G and D693N BRCA1 genotypes and hormone therapy use among postmenopausal women (p for interaction=0.01 and 0.02, respectively). There were no other associations found between BRCA1 genotypes and stage, histologic grade, or nuclear grade. However, the D693N SNP was associated with the risk of triple negative breast cancer (OR=2.31 95% CI: 1.08–4.93). The BRCA1 variants studied may play a role in the etiology of triple negative breast cancer and may interact with environmental factors such as hormone therapy or smoking and increase sporadic breast cancer risk.

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Immunohistochemical tracking of an immune response in mammary Paget’s disease

Cited by 8 publications

References 33 publications

Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway

Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway

Fascin expression in dendritic cells and tumor epithelium in thymoma and thymic carcinoma

BRCA1 Polymorphisms and Breast Cancer Epidemiology in the Western New York Exposures and Breast Cancer (WEB) Study

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