Immunohistochemical study on the distribution of TRPC channels in the rat hippocampus

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

“…TRPC5 is robustly expressed in the hippocampus and amygdala Chung et al, 2006). In the hippocampus of young rats, TRPC5 is expressed on the growth cone where it interacts with stathmin-2 (Greka et al, 2003).…”

Hyperforin: To Be or Not to Be an Activator of TRPC(6)

“…The expression of TRPC channels in the developing as well as in the adult brain makes TRPC channels to interesting targets in the control of growth cone guidance, neurotransmitter release, regulation of synaptic plasticity, and brain development Fusco et al 2004;von Bohlen Und Halbach et al 2005;Chung et al 2006;Faber et al 2006;McGurk et al 2011). With respect to the pharmacological use of hyperforin as antidepressant, the activation of TRPC3 and TRPC6 channels by brain-derived neurotrophic factor via tyrosine kinase receptors (TrK), e.g., TrKB and phospholipase Cγ, is of particular interest (Li et al 2005(Li et al , 2012Amaral and Pozzo-Miller 2007;Sossin and Barker 2007).…”

Alternative Splicing of the TRPC3 Ion Channel Calmodulin/IP3Receptor-Binding Domain in the Hindbrain Enhances Cation Flux

“…Canonical transient receptor potential (TRPC3) nonselective cation channels have broad representation in the brain (Riccio et al, 2002;Chung et al, 2006). The channels are activated by G qprotein-coupled receptor-phospholipase C ␤ (PLC ␤ )-diacylglycerol (DAG) and tyrosine protein kinase receptor-phospholipase C␥-DAG pathways (Birnbaumer, 2009), and are modulated by Ca 2ϩ -calmodulin (CaM) and IP 3 receptor binding.…”