Immunohistochemical Study of Thyroid Transcription Factor-1 Expression in Lung Cancers.

直樹, 石和; 行雄, 中谷; 嘉明, 稲山; 克也, 渡部; 孝光, 前原; 康史, 林; 吉則, 高梨

doi:10.2482/haigan.41.45

Cited by 12 publications

(1 citation statement)

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“…12,17 In lung carcinomas, TTF-1 is expressed in most adenocarcinomas and small cell carcinomas but is rarely expressed in squamous cell carcinoma. 5,20 If a tumor has similar characteristics to basal or progenitor cells of the epithelium, then coexpression of TTF-1 and p63 is understandable.…”

Section: Discussionmentioning

confidence: 99%

NUT Midline Carcinoma

Tanaka

Kato

Gomi

et al. 2012

American Journal of Surgical Pathology

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In this study, we report 2 pediatric cases of nuclear protein of the testis (NUT) midline carcinoma (NMC) suggestive of pulmonary origin: case 1 was a 14-year-old Japanese boy and case 2 was a 7-year-old Japanese girl. Initial symptoms of both cases were prolonged cough and chest pain, and the case 2 patient also complained of lumbago and lumbar mass due to bone metastases. Imaging studies revealed that pulmonary tumors from both patients were located at the hilar region of the lower lobe. Biopsies of the tumors showed undifferentiated carcinoma in case 1 and combined undifferentiated and squamous cell carcinoma in case 2. Despite intensive treatment with chemotherapy and radiation, progression of neither tumor was controlled, and both patients died of the tumors at 1 year (case 1) and 4 months (case 2) after onset of disease. Both tumors were diffusely positive for p63 and NUT expression and were partially positive for various cytokeratins. Reverse transcription polymerase chain reaction analysis and subsequent direct sequencing revealed that the bromodomain-containing protein 4-NUT chimeric gene was present in tumor tissue of both patients, leading to a diagnosis of NMC. The tumor cells of case 1 were also positive for thyroid transcription factor-1 expression, but those of case 2 were negative. Histologic examination of the surgically removed lung tumor of case 1 indicated that the origin of the tumor was basal cells of the bronchiolar epithelia.

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Section: Discussionmentioning

confidence: 99%

NUT Midline Carcinoma

Tanaka

Kato

Gomi

et al. 2012

American Journal of Surgical Pathology

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Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component

Yamaguchi

Sato

et al. 2015

Clin J Gastroenterol

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Small cell carcinoma of the stomach, which is considered synonymous with neuroendocrine carcinoma, is rare. We encountered a case of mixed adenoneuroendocrine carcinoma. Gastrointestinal endoscopy revealed a type 0 IIa + IIc lesion in the stomach. Biopsy suggested well-differentiated adenocarcinoma. Endoscopic submucosal dissection was performed and gastric cancer comprising both well to moderately differentiated adenocarcinoma within the mucous membrane and small cell carcinoma invading to the submucosa with accompanying vessel invasion was found. Mixed adenoneuroendocrine carcinoma was diagnosed and the small cell carcinoma was thyroid transcription factor-1 positive. No tumor lesions were apparent in other organs, so distal gastrectomy and lymph node dissection were performed. Lymph node metastases were not observed. The patient is currently alive without recurrence. Thyroid transcription factor-1-positive gastric neuroendocrine carcinoma is very rare, and the thyroid transcription factor-1-positive rate may contribute to the prediction of prognosis and treatment selection. Accumulation of cases is thus very important.

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