Immunohistochemical Study of the Expression of HLA-DR Antigen and Lymphocyte Infiltration in Human Esophageal Carcinoma

Morita, Mika; Motohiro, Takayuki; Yamanaka, Hideharu; Nakane, Yasushi; Hioki, Koshirou

doi:10.1007/978-4-431-68246-2_86

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“…HLA-DR has been reported as a tumor-associated antigen, present in various kinds of cancers arising from the gastrointestinal tract and other human organs, including meningiomas [3], melanomas [4], and lung cancers [9,10]. We earlier revealed that HLA-DR was expressed by colorectal, esophageal [6], gastric [2], and pancreatic tumor cells [I I]. Moreover, such HLA-DR expression was found to closely correlate with the distribution of CEA in colorectal cancers [12] and the secretory component (SC) staining pattern in gastric tumors [2]).…”

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confidence: 99%

Immunohistochemically demonstrated expression of HLA‐DR antigen in colorectal adenocarcinomas and its relation to clinicopathological features

Morita¹,

Tanaka²,

Kuroda³

et al. 1995

Journal of Surgical Oncology

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We studied 148 colorectal adenocarcinomas to clarify any correlation between HLA-DR antigen expression on tumor cells and histopathological features. Paraffin sections of formalin-fixed tissues were stained with HLA-DR antigen using the indirect immunoperoxidase technique. All the tumor tissues were divided into two groups, depending on the incidence of HLA-DR-positive cells (greater and lesser than 50%). Carcinoma tissues with a higher incidence showed less mural invasion, lymphoductal invasion, venous invasion, lymphonodular metastasis, and peritoneal metastasis. Tissues with a high HLA-DR reactivity were more often observed for Dukes' A and B stages, whereas those with a low HLA-DR positivity were frequently Dukes' C and D stages. As for the cumulative survival rate, the group with high HLA-DR expression demonstrated significantly better survival. We speculate that HLA-DR expression by colorectal cancer cells exerts a favorable influence on clinical course.

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