Immunohistochemical study of syndecan‐1 down‐regulation and the expression of p53 protein or Ki‐67 antigen in oral leukoplakia with or without epithelial dysplasia

Kurokawa, Hideo; Matsumoto, Shinobu; Murata, Tomoyuki; Yamashita, Yuichi; Tomoyose, Taiki; Zhang, Min; Fukuyama, Hiroshi; Takahashi, Tsuneo

doi:10.1034/j.1600-0714.2003.00117.x

Cited by 62 publications

(62 citation statements)

References 38 publications

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“…Therefore, a genuine reason thus culminated to find out an objective guideline that would attribute collectively and resultantly for an absolutely clear diagnosis. 2 The evaluation of the morphologic profile of the tumor cells is considered to be a determinant factor appropriating the aggressiveness of the tumor. However, at times, the inconspicuous nature of such a profile is found to be inadequate to assign the aggressiveness of the lesion.…”

Section: Introductionmentioning

confidence: 99%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:The aim of the study was to evaluate the proliferative index (PI) at their invasive front of oral cancer and their association with Bryne's grades of oral squamous cell carcinoma (OSCC) and compare the PI with lymph node metastasis, site of involvement, and habits. Materials and methods:The Ki-67 antigen expression was immunohistochemically evaluated in a total of 102 cases that included the histopathologically diagnosed archival specimens of OSCCs. They were subdivided by Bryne's histopathological grading into grade I (40 cases), grade II (32 cases), and grade III (30 cases). The nucleus with brown stain was considered positive. Cells were counted under 400× magnification. The proliferative activity thus determined was then expressed as a percentage of Ki-67 labeling index (Ki-67 LI) positive cells. Results:A stepwise increase in the mean Ki-67 LI was found from grade I to III squamous cell carcinoma, thus correlating with the histological grading. In addition, there was a higher PI seen in cases associated with metastatic lymph node, which concords with the higher biologic aggressiveness and poor prognosis of the lesion. Conclusion:The present study shows a definitive correlation of Ki-67 antigen with the Bryne's histological grading, all the parameters of Bryne's grading for OSCC and lymph node status of the patient proving its association as an effective tool to grade the tumors and finally read the prognosis of the tumor. Clinical significance: Cell proliferation is regarded as one of the most important biologic mechanisms in oncogenesis. The role of cell proliferation in tumor progression has been inferred in studies concerned with human cancer by comparing the PI of normal tissue, preneoplastic and neoplastic lesions. The Ki-67 antigen-labeled cells can prove to be an effective aid to grade the tumors. It might be possible to standardize and objectify tumor grading among pathology laboratories. Proliferative Index in Invasive Tumor

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Section: Introductionmentioning

confidence: 99%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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“…Kurokawa et al (2003) also found a significant correlation between the down-regulation of syndecan-1 expression and the grade of oral epithelial dysplasia. Down-regulation has also been reported in S C C s o f t h e h e a d a n d n e c k c o m p a r e d t o e x p r e s s i o n i n t h e c o r r e s p o n d i n g n o r m a l epithelium (Soukka et al, 2000), suggesting that syndecan-1 was a useful marker for evaluating pre-malignant lesions of the head and neck region.…”

Section: Syndecan-1 In Oral Cancermentioning

confidence: 72%

“…Many immunohistochemical studies have demonstrated absent or decreased expression of syndecan-1 in many kinds of carcinomas with more aggressive characteristics (Fujiya et al, 2001;Inki et al, 1994;Kumar-Singh et al, 1998;Matsumoto et al, 1997;Stanley et al, 1999;Toyoshima et al, 2001;Wiksten et al, 2000;Wiksten et al, 2001). There are several reports on syndecan-1 expression in head and neck carcinoma (Anttonen et al, 1999;Inki et al, 1994;Kurokawa et al, 2003;Kurokawa et al, 2006;Muramatsu et al, 2008;Ro et al, 2006). However, head and neck carcinoma includes oral, nasal, laryngeal and esophageal carcinomas, and investigation of syndecan-1 expression in oral cancer has been limited.…”

Section: Syndecan-1 In Cancermentioning

confidence: 99%

Reduced Expression of Syndecan-1 in Oral Cancer

Muramatsu¹

2012

Oral Cancer

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“…Previous studies have demonstrated that oral leukoplakia and oral squamous cell carcinoma (OSCC) display unique gene expression patterns, including p53 (3)(4)(5), Ki-67 (4,6), and MDM2 (5). Despite the number of studies, the elucidation of reliable prognostic markers for leukoplakia has been unsuccessful.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology

Odani

Ito²,

Li³

et al. 2006

Int J Oncol

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Abstract. Although leukoplakia is the most common precancerous lesion of the oral cavity, its molecular biological properties are largely unknown. The aim of this study was to identify the genes responsible for its pathogenesis and malignant transformation using oligonucleotide microarray technology. The expression profiles of 8,800 genes in human oral leukoplakia (n=4) and oral squamous cell carcinoma (OSCC) (n=2) were analyzed using the Affymetrix GeneChip ® system and the results were confirmed with RT-PCR. Eight genes were up-regulated (>2.0-fold) and ten were downregulated (<0.5-fold) in all leukoplakias analyzed with the GeneChip. In particular, loricrin and keratins displayed greater differences between normal tissue and leukoplakia. Some of the 18 alternatively expressed genes were markedly downregulated in squamous cell carcinoma compared with leukoplakia. Our data suggested that gene abnormalities in cytoskeleton network components might be responsible for the development and progression of oral leukoplakia.

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Immunohistochemical study of syndecan‐1 down‐regulation and the expression of p53 protein or Ki‐67 antigen in oral leukoplakia with or without epithelial dysplasia

Cited by 62 publications

References 38 publications

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Reduced Expression of Syndecan-1 in Oral Cancer

Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology

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